Study | Study design | N | Included patients | Patient characteristics (conventional/conservative) | Conservative oxygen regimen | Conventional oxygen regimen | Follow-up (days) | |||
---|---|---|---|---|---|---|---|---|---|---|
Severe ARF included | Age, mean, (year) | Disease severity | Patients with MV (%) | |||||||
Schjørring et al. [19] | PR, UB, MC | 1441/1447 | Aged ≥18 admitted to ICU with hypoxemic respiratory failure | Yes | 70/70 | SOFA 9/9 | 71/72 | PaO2 target 60 mmHg | PaO2 target 90 mmHg | 90 |
Barrot et al. [11] | PR, UB, MC | 102/103 | Adult patients receiving MV ≤12 h for ARDS | Yes | 64/64 | SOFA 9/9 SAPS III 68/67 | 100/100 | PaO2 target 55–70 mmHg; SpO2 target 88–92% | PaO2 target 90–105 mmHg; SpO2 ≥96% | 90 |
Yang et al. [13] | PR, SB, SC | 114/100 | Aged ≥18 admitted to ICU with expected ICU LOS ≥ 72 h | PiO2 <100 were excluded | 60/56 | APACHE II 17/17 | 84/83 | SpO2 target 90–95%; FiO2 as low as possible | SpO2 target 96–100%; FiO2 no lower than 30% | 28 |
Mackle et al. [12] | PR, SB, MC | 501/499 | Age ≥18 admitted to ICU and expected to receive MV ≥48 h | Yes | 68/65 | APACHE II 22/19 | 100/100 | SpO2 target 90–97% | No specific limiting FiO2 or SpO2 | 250 |
Asfar et al. [2] | PR, UB, MC | 219/223 | Aged ≥18 with septic shock who were on MV | PiO2 <100 were excluded | 58/62 | SOFA 10/10 SAPS III 72/73 | 100/100 | SpO2 target 88–95% | FiO2 of 1.0 for 24 h | 90 |
Girardis et al. [8] | PR, UB, SC | 244/236 | Age ≥18 admitted to ICU with expected ICU LOS ≥72 h | PiO2 <150 were excluded | 65/63 | SAPS II 39/37 | 68/66 | SpO2 target 94–98% or PaO2 target 70–100 mmHg | FiO2 ≥0.4, PaO2 up to 150 mmHg, SpO2 of 97–100% | 60 |
Panwar et al. [18] | PR, UB, MC | 51/53 | Age ≥18 admitted to ICU with expected MV time ≥24 h | Yes | 62/62 | APACHE III 70/80 SOFA 7/8 | 100/100 | SpO2 target 88–92% | SaO2 target ≥96% | 90 |