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Table 1 Characteristics of the studies included in current systemic review and meta-analysis

From: Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials

Study Study design N Included patients Patient characteristics (conventional/conservative) Conservative oxygen regimen Conventional oxygen regimen Follow-up (days)
Severe ARF included Age, mean, (year) Disease severity Patients with MV (%)
Schjørring et al. [19] PR, UB, MC 1441/1447 Aged ≥18 admitted to ICU with hypoxemic respiratory failure Yes 70/70 SOFA 9/9 71/72 PaO2 target 60 mmHg PaO2 target 90 mmHg 90
Barrot et al. [11] PR, UB, MC 102/103 Adult patients receiving MV ≤12 h for ARDS Yes 64/64 SOFA 9/9
SAPS III 68/67
100/100 PaO2 target 55–70 mmHg; SpO2 target 88–92% PaO2 target 90–105 mmHg; SpO2 ≥96% 90
Yang et al. [13] PR, SB, SC 114/100 Aged ≥18 admitted to ICU with expected ICU LOS ≥ 72 h PiO2 <100 were excluded 60/56 APACHE II 17/17 84/83 SpO2 target 90–95%; FiO2 as low as possible SpO2 target 96–100%; FiO2 no lower than 30% 28
Mackle et al. [12] PR, SB, MC 501/499 Age ≥18 admitted to ICU and expected to receive MV ≥48 h Yes 68/65 APACHE II 22/19 100/100 SpO2 target 90–97% No specific limiting FiO2 or SpO2 250
Asfar et al. [2] PR, UB, MC 219/223 Aged ≥18 with septic shock who were on MV PiO2 <100 were excluded 58/62 SOFA 10/10
SAPS III 72/73
100/100 SpO2 target 88–95% FiO2 of 1.0 for 24 h 90
Girardis et al. [8] PR, UB, SC 244/236 Age ≥18 admitted to ICU with expected ICU LOS ≥72 h PiO2 <150 were excluded 65/63 SAPS II 39/37 68/66 SpO2 target 94–98% or PaO2 target 70–100 mmHg FiO2 ≥0.4, PaO2 up to 150 mmHg, SpO2 of 97–100% 60
Panwar et al. [18] PR, UB, MC 51/53 Age ≥18 admitted to ICU with expected MV time ≥24 h Yes 62/62 APACHE III 70/80
SOFA 7/8
100/100 SpO2 target 88–92% SaO2 target ≥96% 90
  1. APACHE, Acute Physiology, Age, and Chronic Health Evaluation; ARDS, acute respiratory distress syndrome; FiO2, fraction of inspiratory oxygen; ICU, intensive care unit; aITT, intention-to-treat analysis; LOS, length of stay; MV, mechanical ventilation; MC, multi-centers; PaO2, partial pressure of arterial oxygen; PiO2, PaO2/FiO2; PR, prospective; SAPA, Simplified Acute Physiology score; SC, single center; SB, single-blind; SOFA, Sequential Organ Failure Assessment; SpO2, pulse oxygen saturation; SARF, severe acute respiratory failure; UB, unblinded