Skip to main content

Table 5 Cox proportional hazards models for prediction of 28-day mortality based on the ATX level and severity score

From: Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome

Variable Univariate Cox model
HR (95% CI)
P value Multivariate Cox model
HR (95% CI)
P value
SOFA (per point) 1.234 (1.084-1.404) 0.001 1.108 (0.938-1.307) 0.227
APACHE II (per point) 1.103 (1.026-1.186) 0.008 1.098 (1.017-1.186) 0.017
PaO2/FIO2 (per 10 mmHg) 0.987 (0.905-1.076) 0.767 0.993 (0.906-1.088) 0.880
BALF ATX (per 1 ng/mL) 1.040 (0.932-1.162) 0.482 1.004 (0.870-1.158) 0.956
Serum ATX (per 20 ng/mL) 2.605 (1.530-4.435) < 0.0001 2.479 (1.200-5.121) 0.014
  1. P values less than 0.05 are statistically significant. APACHE, Acute Physiology and Chronic Health Evaluation; ATX, autotaxin; BALF, bronchoalveolar lavage fluid; CI, confidence interval; FIO2, fraction of inspired oxygen; HR, hazard ratio; PaO2, arterial oxygen tension; SOFA, Sequential Organ Failure Assessment