Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome

Table 5 Cox proportional hazards models for prediction of 28-day mortality based on the ATX level and severity score

Variable	Univariate Cox model HR (95% CI)	P value	Multivariate Cox model HR (95% CI)	P value
SOFA (per point)	1.234 (1.084-1.404)	0.001	1.108 (0.938-1.307)	0.227
APACHE II (per point)	1.103 (1.026-1.186)	0.008	1.098 (1.017-1.186)	0.017
PaO₂/FIO₂ (per 10 mmHg)	0.987 (0.905-1.076)	0.767	0.993 (0.906-1.088)	0.880
BALF ATX (per 1 ng/mL)	1.040 (0.932-1.162)	0.482	1.004 (0.870-1.158)	0.956
Serum ATX (per 20 ng/mL)	2.605 (1.530-4.435)	< 0.0001	2.479 (1.200-5.121)	0.014

P values less than 0.05 are statistically significant. APACHE, Acute Physiology and Chronic Health Evaluation; ATX, autotaxin; BALF, bronchoalveolar lavage fluid; CI, confidence interval; FIO₂, fraction of inspired oxygen; HR, hazard ratio; PaO₂, arterial oxygen tension; SOFA, Sequential Organ Failure Assessment

ISSN: 2052-0492