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Table 3 Correlations between ATX and a panel of biomarkers

From: Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome

Biomarkers

BALF

Serum

Spearman’s rank (95% CI)

P value

Spearman’s rank (95% CI)

P value

IL-6

0.552 (0.297-0.734)

0.0001

0.511 (0.260-0.697)

0.0002

IL-8

0.289 (−0.003-0.536)

0.0460

0.313 (0.033-0.548)

0.0254

TNF-α

0.562 (0.331-0.729)

< 0.0001

0.245 (−0.038-0.492)

0.0803

MMP-7

0.446 (0.186-0.647)

0.0010

0.471 (0.219-0.664)

0.0004

Fibronectin

0.702 (0.516-0.825)

< 0.0001

0.060 (−0.224-0.335)

0.6714

OSM

0.508 (0.262-0.692)

0.0001

0.268 (−0.014-0.510)

0.0550

SPARC

0.620 (0.408-0.768)

< 0.0001

−0.078 (−0.351-0.207)

0.5828

BA/SA ration (‰)

0.658 (0.502-0.772)

< 0.0001

−0.014 (−0.237-0.210)

0.9024

  1. P values less than 0.05 are statistically significant. ARDS, acute respiratory distress syndrome; ATX, autotaxin; BA, BALF albumin; BALF, bronchoalveolar lavage fluid; CI, confidence interval; IL-6, interleukin-6; IL-8, interleukin-8; MMP-7, matrix metalloproteinase-7; OSM, oncostatin M; SA, serum albumin; SPARC, secreted protein acidic and rich in cysteine; TNF-α, tumor necrosis factor-alpha
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Journal of Intensive Care

ISSN: 2052-0492