Skip to main content

Table 3 Correlations between ATX and a panel of biomarkers

From: Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome

Biomarkers BALF Serum
Spearman’s rank (95% CI) P value Spearman’s rank (95% CI) P value
IL-6 0.552 (0.297-0.734) 0.0001 0.511 (0.260-0.697) 0.0002
IL-8 0.289 (−0.003-0.536) 0.0460 0.313 (0.033-0.548) 0.0254
TNF-α 0.562 (0.331-0.729) < 0.0001 0.245 (−0.038-0.492) 0.0803
MMP-7 0.446 (0.186-0.647) 0.0010 0.471 (0.219-0.664) 0.0004
Fibronectin 0.702 (0.516-0.825) < 0.0001 0.060 (−0.224-0.335) 0.6714
OSM 0.508 (0.262-0.692) 0.0001 0.268 (−0.014-0.510) 0.0550
SPARC 0.620 (0.408-0.768) < 0.0001 −0.078 (−0.351-0.207) 0.5828
BA/SA ration (‰) 0.658 (0.502-0.772) < 0.0001 −0.014 (−0.237-0.210) 0.9024
  1. P values less than 0.05 are statistically significant. ARDS, acute respiratory distress syndrome; ATX, autotaxin; BA, BALF albumin; BALF, bronchoalveolar lavage fluid; CI, confidence interval; IL-6, interleukin-6; IL-8, interleukin-8; MMP-7, matrix metalloproteinase-7; OSM, oncostatin M; SA, serum albumin; SPARC, secreted protein acidic and rich in cysteine; TNF-α, tumor necrosis factor-alpha