Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome

Table 1 Baseline characteristics of patients with ARDS

Variables	ARDS survivors (n = 31)	ARDS non-survivors (n = 21)	P value
Age, years	32.03 ± 22.12	55.76 ± 17.20	0.280
Male, sex – no. (%)	22 (70.97%)	17 (80.95%)	0.415
BMI, kg/m²	25.37 ± 3.08	25.58 ± 2.57	0.800
Cause of ARDS – no. (%)			0.158
Direct (intrapulmonary) lung injury	18 (58.06%)	8 (38.10%)
Indirect (extrapulmonary) lung injury	13 (41.94%)	13 (61.90%)
Risk factor for ARDS – no. (%)			0.347
Pneumonia	17 (54.84%)	6 (28.57%)
Sepsis	6 (19.35%)	3 (14.29%)
Surgery	3 (9.68%)	4 (19.05%)
Pulmonary contusion	1 (3.23%)	2 (9.52%)
Trauma	1 (3.23%)	2 (9.52%)
Other	3 (9.68%)	4 (19.05%)
PaO₂/FIO₂, mmHg	114.59 ± 46.26	114.46 ± 64.49	0.994
APACHE II score	17.39 ± 6.07	21.05 ± 6.98	0.050
SOFA score	9.61 ± 2.87	12.95 ± 3.58	0.010
Mechanical ventilation setting
Tidal volume, mL	425.63 ± 49.74	433.26 ± 144.60	0.800
PEEP (cmH2O)	6.26 ± 3.41	7.11 ± 3.11	0.395
pH	7.38 ± 0.11	7.31 ± 0.13	0.062
Length of stay in ICU stay – days	13.74 ± 16.30	8.10 ± 8.00	0.148

Data are presented as the mean ± standard deviation or as the median (interquartile range). Statistical significance was set at P < 0.05. APACHE, Acute Physiology and Chronic Health Evaluation; ARDS, acute respiratory distress syndrome; BMI, body mass index; FIO₂, fraction of inspired oxygen; ICU, intensive care unit; PaO₂, arterial oxygen tension; PEEP, positive end-expiratory pressure; SOFA, Sequential Organ Failure Assessment

ISSN: 2052-0492