Fig. 3

Ability of serum ATX to predict mortality in patients with ARDS. Receiver operating characteristic curve analysis of the ability of the serum ATX level to predict mortality in patients with ARDS was higher than that of serum MMP-7 (A), BALF IL-8 (A), the SOFA score (A), the APACHE II score (A), or the PaO₂/FIO₂ ratio (A). A combination of the serum ATX level and the SOFA score, APACHE II score, and PaO₂/FIO₂ ratio could help to predict the prognosis of ARDS (B). Kaplan–Meier curves show that the survival rate of patients stratified with a cutoff value of 36.96 ng/mL for serum ATX was significantly lower than that of patients with a lower ATX level (P < 0.0001, log-rank test) (C). APACHE, Acute Physiology and Chronic Health Evaluation; ARDS, acute respiratory distress syndrome; ATX, autotaxin; AUC, area under the receiver operating characteristic curve; BALF, bronchoalveolar lavage fluid; FIO₂, fraction of inspired oxygen; IL-8, interleukin-8; MMP-7, matrix metalloproteinase-7; PaO₂, arterial oxygen tension; SOFA, Sequential Organ Failure Assessment