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Table 11 Evidence profile (IL-6 in the ICU)

From: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)

  1. a Observational studies only, and the biases of 6 studies were high against markers (indices)
  2. b Q level, p-value < 0.05: heterogeneity present, 95%CI overlap: insufficient I2 > 90
  3. c Wide confidence interval and large number of false negatives, particularly when the prevalence was high