All (N=100) | ACP12h≤68.78% (n=58) | ACP12h>68.78% (n=42) | P value | |
---|---|---|---|---|
Demographics | ||||
Age, mean (SD), year | 67.7 (15.4) | 70.3 (15.2) | 63.9 (15.0) | 0.040 |
Male, No. (%) | 62 (62.0) | 33 (56.9) | 29 (69.0) | 0.217 |
BMI, mean (SD), kg/m2 | 21.7 (4.2) | 21.6 (4.3) | 21.7 (4.2) | 0.877 |
Severity of illness on the beginning of septic shock, mean (SD) or median (IQR) | ||||
APACHE-II score | 23.8 (8.9) | 25.4 (9.1) | 21.7 (8.3) | 0.037 |
Vasoactive inotropic score | 103.5 (20.8–174.5) | 137.2 (73.4–220.9) | 27.7 (0.7–102.5) | < 0.001 |
Vital signs, mean (SD) or median (IQR) | ||||
MAP, mmHg | 80.1 (13.2) | 72.9 (9.9) | 90.0 (10.6) | <0.001 |
Respiratory rate, times/min | 26.0 (20.0–34.8) | 25.0 (20.0–32.0) | 29.5 (20.8–37.3) | 0.135 |
Heart rate, beats/min | 117.2 (26.8) | 117.4 (27.6) | 117.0 (26.0) | 0.948 |
Body temperature, °C | 37.0 (36.2–38.0) | 37.0 (36.3–38.0) | 37.0 (36.0–38.0) | 0.916 |
Focus of infection, NO. (%) | ||||
Bloodstream infection | 18 (18.0) | 9 (15.5) | 9 (21.4) | 0.448 |
Pulmonary infection | 37 (37.0) | 19 (32.8) | 18 (42.9) | 0.302 |
Abdominal infection | 23 (23.0) | 13 (22.4) | 10 (23.8) | 0.870 |
Urinary infection | 3 (3.0) | 3 (5.2) | 0 (0.0) | 0.135 |
Infection of biliary tract | 7 (7.0) | 5 (8.6) | 2 (4.8) | 0.455 |
Skin soft-tissue infection | 1 (1.0) | 1 (1.7) | 0 (0.0) | 0.392 |
Other | 11 (11.0) | 8 (13.8) | 3 (7.1) | 0.294 |
Medical history, No. (%) | ||||
Chronic heart disease | 17 (17.0) | 12 (20.7) | 5 (11.9) | 0.248 |
Chronic kidney disease | 10 (10.0) | 6 (10.3) | 4 (9.5) | 0.893 |
Diabetics | 12 (12.0) | 7 (12.1) | 5 (11.9) | 0.980 |
Hypertension | 12 (12.0) | 6 (10.3) | 6 (14.3) | 0.549 |
Combined therapy | ||||
Mechanical ventilation, No. (%) | 95 (95.0) | 55 (94.8) | 40 (95.2) | 0.926 |
CRRT, No. (%) | 59 (59.0) | 40 (69.0) | 19 (45.2) | 0.017 |
Day-1 total amount, mean (SD), mla | 3935.2 (1500.9) | 4365.6 (1568.3) | 3340.8 (1181.4) | 0.001 |
Day-1 output, mean (SD), mlb | 2447.8 (1386.5) | 2385.6 (1379.9) | 2533.9 (1407.7) | 0.600 |
Day-1 volume, mean (SD), mlc | 1487.3 (1831.0) | 1980.0 (1932.3) | 806.9 (1444.5) | 0.001 |
Outcomes | ||||
Day-7 mortality, No. (%) | 34 (34.0) | 30 (51.7) | 4 (9.5) | <0.001 |
Day-14 mortality, No. (%) | 47 (47.0) | 39 (67.2) | 8 (19.0) | <0.001 |
Day-28 mortality, No. (%) | 57 (57.0) | 43 (74.1) | 14 (33.3) | <0.001 |
ICU mortality, No. (%) | 58 (58.0) | 43 (74.1) | 15 (35.7) | < 0.001 |
ICU LOS, median (IQR), d | 9.0 (5.0–17.8) | 8.0 (3.0–13.3) | 12.5 (6.8–20.8) | 0.018 |
Hospital mortality, No. (%) | 61 (61.0) | 44 (75.9) | 17 (40.5) | < 0.001 |
Hospital LOS, median (IQR), d | 22.0 (11.0–32.8) | 15.5 (6.8–28.0) | 23.5 (15.5–40.3) | 0.006 |
PICCO data, mean (SD) or median (IQR) | ||||
CVP, cmH2O | 14.7 (5.9) | 16.0 (6.1) | 12.9 (5.2) | 0.009 |
GEDI, ml/m2 | 707.0 (605.5–842.3) | 698.0 (599.3–861) | 712.0 (616.8–817.5) | 0.992 |
SVRI, dyn.s.cm-5.m2 | 2063.7 (792.6) | 2119.7 (921.3) | 1986.5 (571.1) | 0.376 |
ELWI, ml/kg | 9.0 (6.6–14.5) | 9.2 (7.0–15.0) | 8.2 (6.0–13.6) | 0.206 |
CI, L/min/m2 | 3.09 (0.98) | 2.77 (0.98) | 3.55 (0.79) | <0.001 |
CPI, W/m2 | 0.55 (0.20) | 0.44 (0.16) | 0.70 (0.16) | <0.001 |
LVEF, median (IQR), % | ||||
LVEF | 60.0 (55.0–64.8) | 58.7 (54.0–63.3) | 62.0 (59.4–65.3) | 0.006 |
Laboratory test, mean (SD) or median (IQR) | ||||
White blood cell, ×109/L | 10.8 (6.1–19.1) | 12.8 (6.2–21.2) | 8.7 (5.8–15.6) | 0.180 |
Neutrophils lymphocytes ratio | 21.8 (26.4) | 22.7 (27.6) | 20.6 (24.9) | 0.702 |
Hemoglobin, g/L | 94.6 (24.4) | 92.1 (23.8) | 98.1 (25.0) | 0.229 |
Platelet, ×109/L | 99.0 (41.0–191.5) | 72.5 (33.8–186.8) | 129.5 (54.8–208.3) | 0.051 |
Total bilirubin, μmol/L | 23.5 (13.0–45.5) | 35.0 (13.8–55.7) | 16.7 (11.0–29.3) | 0.005 |
Albumin, g/L | 25.3 (4.8) | 24.6 (4.9) | 26.4 (4.6) | 0.061 |
Serum creatinine, μmol/L | 156.9 (92.4–229.5) | 161.2 (95.9–234.7) | 125.6 (86.6–222.1) | 0.311 |
Urea, mmol/L | 12.0 (8.0–17.9) | 11.8 (7.4–19.0) | 12.2 (8.1–16.0) | 0.810 |
Calcium ion, mmol/L | 1.98 (1.87–2.17) | 2.00 (1.89–2.17) | 1.97 (1.87–2.18) | 0.722 |
D-dimer, mg/L | 5.3 (3.1–10.0) | 5.1 (3.2–15.8) | 6.2 (2.8–8.4) | 0.603 |
Fibrinogen, g/L | 3.6 (1.8) | 3.3 (1.7) | 4.1 (1.8) | 0.023 |
Procalcitonin, ng/ml | 24.4 (3.0–56.7) | 31.6 (5.3–58.4) | 19.0 (1.0–56.4) | 0.336 |
Lactate, mmol/L | 4.8 (2.0–8.9) | 5.6 (2.3–12.1) | 3.8 (1.9–5.6) | 0.006 |