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Table 4 Hemodynamics in patients with a decrease in systolic or diastolic blood pressure after intravenous paracetamol administration

From: Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support

Hemodynamic parametersTime after intravenous administration (no. of doses)
 30 min60 min90 min120 min
 Negative change in systolic blood pressure
(50)(67)(61)(59)
Mean drop in systolic pressure from T0 (mmHg)− 12 ± 9 (− 7; − 14)− 15 ± 12 (−5; − 22)− 14 ± 13 (−5; − 21)− 14 ± 12 (− 5; − 17)
Mean Δ from lower limit of normal systolic pressure (mmHg)8 ± 14 (− 2; 15)3 ± 14 (− 9; 14)2 ± 15 (− 8; 14)5 ± 14 (−  2; 15)
Mean Δ from systolic hypotension value (mmHg)22 ± 12 (12; 29)17 ± 13 (6; 26)16 ± 12 (8; 26)19 ± 13 (9; 26)
Number of patients with systolic hypotension02 (− 1a, − 16a)1 (− 1a)2 (− 13a; − 5a)
 Negative change in diastolic blood pressure
N = 53N = 59N = 50N = 52
Mean drop in diastolic pressure from T0 (mmHg)− 7 ± 5 (− 11; − 3)− 9 ± 7 (− 4; − 13)− 9 ± 6 (− 4; − 13)− 9 ± 7 (− 3; − 13)
Mean Δ from diastolic hypotension value (mmHg)2 ± 12 (− 8; 11)1 ± 14 (− 8; 12)0 ± 14 (− 9; 9)1 ± 13 (− 8; 9)
  1. Values given as mean ± SD, (IQR) unless otherwise indicated
  2. Δ delta, T0 time immediately before paracetamol transfusion
  3. ammHg below lowest normal systolic value for age