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Table 4 Hemodynamics in patients with a decrease in systolic or diastolic blood pressure after intravenous paracetamol administration

From: Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support

Hemodynamic parameters

Time after intravenous administration (no. of doses)

 

30 min

60 min

90 min

120 min

 

Negative change in systolic blood pressure

(50)

(67)

(61)

(59)

Mean drop in systolic pressure from T0 (mmHg)

− 12 ± 9 (− 7; − 14)

− 15 ± 12 (−5; − 22)

− 14 ± 13 (−5; − 21)

− 14 ± 12 (− 5; − 17)

Mean Δ from lower limit of normal systolic pressure (mmHg)

8 ± 14 (− 2; 15)

3 ± 14 (− 9; 14)

2 ± 15 (− 8; 14)

5 ± 14 (−  2; 15)

Mean Δ from systolic hypotension value (mmHg)

22 ± 12 (12; 29)

17 ± 13 (6; 26)

16 ± 12 (8; 26)

19 ± 13 (9; 26)

Number of patients with systolic hypotension

0

2 (− 1a, − 16a)

1 (− 1a)

2 (− 13a; − 5a)

 

Negative change in diastolic blood pressure

N = 53

N = 59

N = 50

N = 52

Mean drop in diastolic pressure from T0 (mmHg)

− 7 ± 5 (− 11; − 3)

− 9 ± 7 (− 4; − 13)

− 9 ± 6 (− 4; − 13)

− 9 ± 7 (− 3; − 13)

Mean Δ from diastolic hypotension value (mmHg)

2 ± 12 (− 8; 11)

1 ± 14 (− 8; 12)

0 ± 14 (− 9; 9)

1 ± 13 (− 8; 9)

  1. Values given as mean ± SD, (IQR) unless otherwise indicated
  2. Δ delta, T0 time immediately before paracetamol transfusion
  3. ammHg below lowest normal systolic value for age