Table 2 SUP criteria used in the ICU

Major adaptation criteria, at least one of the following

 Coagulopathy (platelets < 50 × 10³/mm³ and/or APTT < 50% and/or PT-INR ≥ 1.5)

 Mechanical ventilation for more than 48 h

 A history of UGIB within 1 year

 Glasgow Coma Scale ≤ 10

 Thermal injuries to > 35% of their body surface area

 Post partial hepatectomy

 Multiple trauma (Injury Severity Score ≥ 16) [10]

 Transplantation patients

 Hepatic failure

 Spinal cord injury

Minor adaptation criteria, at least two of the following

 Sepsis

 ICU stay for more than 7 days

 Occult bleeding lasting 6 days or more

 Corticosteroids (> 250 mg/day of hydrocortisone or the equivalent)

Exclusion criteria: SUP is not required if one of the following

 Enteral nutrition has been already administered

 Early exit from the ICU is expected