| |
rhTM group (n = 52)
|
Non-rhTM group (n = 45)
|
Regression coefficient
|
OR (95% CI)
|
P value
|
|---|
|
Primary outcome
|
|
Dependence on RRT at ICU discharge—no. (%)
|
21 (40.4)
|
28 (62.2)
|
− 0.86
|
0.43 (0.19–0.97)
|
0.043
|
|
Secondary outcomes
|
|
Serum creatinine level (mg/dL)
|
|
at ICU admission
|
2.00 (1.19–2.87)
|
2.30 (1.50–3.14)
|
− 0.39
|
0.67 (0.30–1.52)
|
0.34
|
|
at ICU discharge
|
1.22 (0.77–1.75)
|
2.23 (1.09–2.94)
|
− 1.18
|
0.31 (0.13–0.72)
|
0.007
|
|
at hospital discharge
|
1.00 (0.74–1.62)
|
1.98 (1.04–2.94)
|
− 1.37
|
0.25 (0.11–0.60)
|
0.002
|
|
RRT-free days for 28 days
|
15 (0–21)
|
0 (0–21)
|
1.06
|
2.89 (1.24–6.74)
|
0.014
|
|
ICU-free days for 28 days
|
13 (0–20)
|
0 (0–17)
|
0.90
|
2.47 (1.07–5.67)
|
0.033
|
|
Ventilator-free days for 28 days
|
20 (0–23)
|
0 (0–24)
|
1.20
|
3.31 (1.41–7.75)
|
0.006
|
|
Mortality
|
|
ICU—no. (%)
|
18 (34.6)
|
22 (48.9)
|
− 0.59
|
0.56 (0.24–1.28)
|
0.17
|
|
28 days—no. (%)
|
15 (28.8)
|
23 (51.0)
|
− 0.92
|
0.40 (0.17–0.93)
|
0.033
|
- Data are presented as medians (IQR). The ICU-free and mechanical ventilation-free days were calculated according to the number of days in which the patient was alive and did not receive the specified therapy during the first 28 days after enrollment; patients who died were assigned as having 0 free days. The number of RRT-free days was calculated according to the number of days in which the patient did not receive RRT during the first 28 days after enrollment
- RRT renal replacement therapy, ICU intensive care unit, IQR interquartile range, OR odds ratio, 95% CI 95% confidence interval, rhTM recombinant human soluble thrombomodulin
