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Table 1 Characteristics of the patients

From: The effect of recombinant human soluble thrombomodulin on renal function and mortality in septic disseminated intravascular coagulation patients with acute kidney injury: a retrospective study

  rhTM group (n = 52) Non-rhTM group (n = 45) P value
Age (years) 66 (54–74) 65 (51–73) 0.90
Male, n (%) 35 (67.3) 35 (77.8) 0.27
Body mass index 22.1 (19.4–24.0) 23.1 (20.6–25.9) 0.23
APACHE II 25 (22–27) 25 (21–30) 0.33
SOFA score at ICU admission 9 (6–10) 9 (7–11) 0.34
Focus of infection
 Abdomen 22 15  
 Lung 19 16  
 Urogenital tract 3 3  
 Skin and soft tissue 3 2  
 CRBSI 2 1  
 Miscellaneous 3 8  
Septic shock, n (%) 37 (71.2) 33 (73.3) 0.83
DIC score
 JAAM DIC 6 (5–7) 6 (5–7) 0.52
 ISTH overt DIC 6 (5–6) 6 (4–6) 0.76
Anticoagulants, n (%)
 rhTM 52 (100) -  
 Heparin - 18 (40)  
 Antithrombin 30 (57.7) 18 (40) 0.10
 Others - 8 (17.8)  
Steroids, n (%) 32 (61.5) 18 (40) 0.16
KDIGO classification    0.57
 Stage 1 16 17  
 Stage 2 19 12  
 Stage 3 17 16  
Timing of RRT from ICU admission (h) 3.8 (2.0–7.9) 4.0 (3.0–5.8) 0.67
  1. Data are presented as medians (IQR). The body mass index is the weight in kilograms divided by the square of the height in meters. The SOFA score ranges from 0 to 24, with higher scores indicating more severe organ failure. The APACHE II score ranges from 0 to 71, with higher scores indicating more severe disease and a higher risk of death. Acute kidney injury was defined according to the KDIGO classification. Stage 3 of the KDIGO classification is defined as a serum creatinine level three times the baseline level or an increase of ≥ 4.0 mg per deciliter, oliguria (urine output < 0.3 mL per kilogram of body weight per hour for ≥ 24 h), or anuria for ≥ 2 h. The baseline serum creatinine levels were determined using values measured at 12 months preceding the ICU stay or were estimated
  2. ICU intensive care unit, IQR interquartile range, CRBSI catheter-related bloodstream infections, DIC disseminated intravascular coagulation, JAAM Japanese Association for Acute Medicine, ISTH International Society on Thrombosis and Haemostasis, RRT renal replacement therapy, rhTM recombinant human soluble thrombomodulin, SOFA Sequential Organ Failure Assessment, APACHE II Acute Physiology and Chronic High Evaluation II, KDIGO Kidney Disease Improving Global Outcomes