All-cause 28- or 30-day mortality
|
389 per 1000
|
109 fewer per 1000 (170 fewer to 38 fewer)
|
0.61 (044–0.85)
|
742 (4 RCTs)
|
Moderatea
|
All-cause 60-day mortality
|
381 per 1000
|
121 fewer per 1000 (183 fewer to 43 fewer)
|
0.57 (040–0.83)
|
565 (3 RCTs)
|
Moderatea
|
Ventilator-free days at 28 days
| |
MD 3.74 more (1.53 more to 5.95 more)
| |
742 (4 RCTs)
|
Lowa,b
|
PaO2/FiO2 at days 6 or 7
| |
MD 54.22 more (33.5 more to 74.93 more)
| |
494 (3 RCTs)
|
Very lowa,c
|
Hyperglycemia
|
687 per 1000
|
82 more per 1000 (8 more to 142 more)
|
1.52 (1.04–2.21)
|
565 (3 RCTs)
|
Moderatea
|
Nosocomial infections
|
232 per 1000
|
28 fewer per 1000 (81 fewer to 36 more)
|
0.85 (0.59–1.21)
|
742 (4 RCTs)
|
Lowa,d
|
Gastrointestinal bleeding
|
31 per 1000
|
12 more per 1000 (19 fewer to 110 more)
|
1.39 (0.38–5.06)
|
374 (2 RCTs)
|
Lowa,d
|