Table 1 Summary of findings

All-cause 28- or 30-day mortality

389 per 1000

109 fewer per 1000 (170 fewer to 38 fewer)

0.61 (044–0.85)

742 (4 RCTs)

Moderate^a

All-cause 60-day mortality

381 per 1000

121 fewer per 1000 (183 fewer to 43 fewer)

0.57 (040–0.83)

565 (3 RCTs)

Moderate^a

Ventilator-free days at 28 days

MD 3.74 more (1.53 more to 5.95 more)

742 (4 RCTs)

Low^a,b

PaO₂/FiO₂ at days 6 or 7

MD 54.22 more (33.5 more to 74.93 more)

494 (3 RCTs)

Very low^a,c

Hyperglycemia

687 per 1000

82 more per 1000 (8 more to 142 more)

1.52 (1.04–2.21)

565 (3 RCTs)

Moderate^a

Nosocomial infections

232 per 1000

28 fewer per 1000 (81 fewer to 36 more)

0.85 (0.59–1.21)

742 (4 RCTs)

Low^a,d

Gastrointestinal bleeding

31 per 1000

12 more per 1000 (19 fewer to 110 more)

1.39 (0.38–5.06)

374 (2 RCTs)

Low^a,d