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Table 2 Statistical analysis of the patient characteristics with one-way analysis of variance and post hoc Tukey test

From: The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome

  One-way ANOVA (p) Post hoc 1–2 (p) Post hoc 1–3 (p) Post hoc 2–3 (p) 95% CI 1–2 95% CI 1–3 95% CI 2–3
Baseline parameters
 IL 6 d1 0.286 0.999 0.374 0.304 − 254–263 − 458–129 − 443–105
 CRP d1 0.805 0.861 0.813 0.985 − 8.08–5.19 − 9.47–5.62 − 7.52–6.54
 Creatinine d1 < 0.001 0.702 < 0.001 < 0.001 − 0.7–0.4 1.7 to0.5 1.5 to0.3
 Urea d1 0.001 0.260 0.001 0.021 − 35–7 64 to16 48 to3
 CLCR d1 < 0.001 0.002 < 0.001 0.007 17–88 61–138 11–83
 RRT d1 0.066 0.832 0.066 0.146 − 0.3–0.2 − 0.6–0.02 − 0.5–0.06
 Bilirubin d1 0.499 0.947 0.677 0.475 − 1.5–1.9 − 2.6–1.2 − 2.6–0.9
 ALT d1 0.723 0.781 0.754 0.988 − 174–306 − 196–361 − 249–281
 AST d1 0.728 0.938 0.900 0.706 − 308–230 − 250–361 − 191–379
 GGT d1 0.283 0.931 0.482 0.261 − 108–145 − 213–75 − 222–46
 APACHE II d1 0.026 0.989 0.061 0.03 − 5.0–5.6 − 11.8–0.2 − 11.7 to − 0.5
 SOFA d1 0.133 0.123 0.338 0.703 − 4.3–1.1 − 5.7–0.5 − 3.8–1.9
 Age 0.010 0.204 0.007 0.183 − 17.1–2.8 − 26.3 to − 3.6 − 18.4–2.7
 BMI 0.845 1.00 0.874 1.00 − 11.0–11.0 − 10.0–15.1 − 9.1–14.3
 Sex 0.78 0.82 0.806 0.994 − 0.5–0.3 − 0.6–0.3 − 0.4–0.4
Delta parameters
 ΔIL-6 (d1–d3) 0.236 0.959 0.255 0.319 − 291–231 − 494–100 − 444–109
 ΔCRP (d1–d3) 0.015 0.033 0.026 0.903 11.2 to0.4 12.9 to0.67 − 6.7–4.7
 ΔCreatinine (d1–d5) 0.253 0.900 0.236 0.37 − 0.4–0.6 − 0.2–1.1 − 0.3–1.0
 ΔUrea (d1–d5) 0.327 0.79 0.657 0.298 − 34–20 − 21–45 − 12–50
 ΔCLCR (d1–d5) 0.419 0.398 0.891 0.763 − 22–73 − 45–66 − 67–37
 ΔBilirubin (d1–d5) 0.946 0.957 1.00 0.961 − 1.3–1.7 − 1.7–1.7 − 1.7–1.4
 ΔALT (d1–d5) 0.526 0.632 0.553 0.978 − 174–306 − 196–361 − 249–281
 ΔAST (d1–d5) 0.781 0.999 0.841 0.782 − 242–232 − 206–330 − 175–310
 ΔGGT (d1–d5) 0.765 0.951 0.750 0.869 − 190–244 − 171–319 − 175–268
 ΔAPACHE II (d1–d5) 0.227 0.358 0.231 0.887 − 1.3–4.7 − 1.0–5.6 − 2.4–3.6
 ΔSOFA (d1–d5) 0.215 0.197 0.766 0.597 − 1.7–10.3 − 4.8–8.6 − 10.3–1.7
Neurological disorder d5 0.43 0.473 0.518 0.997 − 0.6–0.2 − 0.6–0.2 − 0.4–0.4
In-hospital mortality 0.002 0.728 0.001 0.017 − 0.2 – 0.4 0.7 to0.06 0.8 to0.2
Estimated mortality 0.123 0.996 0.198 0.135 − 0.1 – 0.1 − 0.3–0.05 − 0.3–0.03
  1. ANOVA analysis of variance, CI confidence interval, IL-6 interleukin-6, CRP C-reactive protein, ALT serum alanine aminotransferase, AST serum aspartate aminotransferase, GGT glutamine glutamyl transferase, CLCR creatinine clearance, RRT renal replacement therapy, d day, BMI body mass index