| Univariate logistic regression analysis | Multivariate logistic regression analysis | ||||
---|---|---|---|---|---|---|
Variable | HR | 95% C.I. | p | HR | 95% C.I. | p |
Age | 1.067 | 1.029–1.107 | < 0.001 | 1.073 | 1.032–1.116 | < 0.001 |
Sex (M) | 1.120 | 0.735–1.709 | 0.597 | – |  |  |
BMI | 0.992 | 0.945–1.042 | 0.761 | – |  |  |
SOFA score at ICU admission | 1.215 | 1.095–1.349 | < 0.001 | 1.142 | 1.007–1.295 | 0.038 |
SAPS II score | 1.042 | 1.022–1.063 | < 0.001 | – |  |  |
Hypertension | 1.906 | 1.182–3.073 | 0.008 | – |  |  |
Chronic ischemic heart disease | 1.053 | 0.556–1.992 | 0.875 | – |  |  |
COPD (oxygen therapy/CPAP) | 1.454 | 0.060–35.34 | 0.818 | – |  |  |
Chronic kidney disease (CKD) | 1.599 | 0.706–3.617 | 0.260 | – |  |  |
CKD – dialisys | 5.595 | 0.512–61.132 | 0.158 | – |  |  |
Diabetes | 3.583 | 0.793–16.195 | 0.097 | – |  |  |
Chronic liver disease (MELD > 10) | 3.583 | 0.793–16.195 | 0.097 | – |  |  |
Renal replacement therapy during ICU stay | 2.885 | 2.265–3.675 | < 0.001 | 2.115 | 1.037–4.310 | 0.039 |
Early onset VAP | 1.574 | 0.797–3.108 | 0.192 | – |  |  |
Late-onset VAP | 1.190 | 0.787–1.812 | 0.410 | – |  |  |
Lowest PaO2/FiO2 within 5 daysa | 0.396 | 0.248–0.631 | < 0.001 | 0.383 | 0.239–0.613 | < 0.001 |
CRS < 40 mL/cmH2O within 5 days | 2.844 | 2.221–3.642 | < 0.001 | 3.193 | 2.525–4.040 | < 0.001 |
Cardiovascular complications | 4.701 | 2.807–7.874 | < 0.001 | 4.600 | 2.474–8.554 | < 0.001 |
Neurologic complications | 0.673 | 0.233–1.947 | 0.465 | – |  |  |
Gastrointestinal complications | 0.749 | 0.288–1.952 | 0.555 | – |  |  |
Extrapulmonary infections | 0.877 | 0.488–1.578 | 0.662 | – |  |  |