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Table 4 Multivariate logistic regression analysis, dependant variable death during ICU stay

From: Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

  Univariate logistic regression analysis Multivariate logistic regression analysis
Variable HR 95% C.I. p HR 95% C.I. p
Age 1.067 1.029–1.107 < 0.001 1.073 1.032–1.116 < 0.001
Sex (M) 1.120 0.735–1.709 0.597   
BMI 0.992 0.945–1.042 0.761   
SOFA score at ICU admission 1.215 1.095–1.349 < 0.001 1.142 1.007–1.295 0.038
SAPS II score 1.042 1.022–1.063 < 0.001   
Hypertension 1.906 1.182–3.073 0.008   
Chronic ischemic heart disease 1.053 0.556–1.992 0.875   
COPD (oxygen therapy/CPAP) 1.454 0.060–35.34 0.818   
Chronic kidney disease (CKD) 1.599 0.706–3.617 0.260   
CKD – dialisys 5.595 0.512–61.132 0.158   
Diabetes 3.583 0.793–16.195 0.097   
Chronic liver disease (MELD > 10) 3.583 0.793–16.195 0.097   
Renal replacement therapy during ICU stay 2.885 2.265–3.675 < 0.001 2.115 1.037–4.310 0.039
Early onset VAP 1.574 0.797–3.108 0.192   
Late-onset VAP 1.190 0.787–1.812 0.410   
Lowest PaO2/FiO2 within 5 daysa 0.396 0.248–0.631 < 0.001 0.383 0.239–0.613 < 0.001
CRS < 40 mL/cmH2O within 5 days 2.844 2.221–3.642 < 0.001 3.193 2.525–4.040 < 0.001
Cardiovascular complications 4.701 2.807–7.874 < 0.001 4.600 2.474–8.554 < 0.001
Neurologic complications 0.673 0.233–1.947 0.465   
Gastrointestinal complications 0.749 0.288–1.952 0.555   
Extrapulmonary infections 0.877 0.488–1.578 0.662   
  1. Notes: AUC of the ROC curve for the multivariate model: 0.818
  2. Abbreviations: HR hazard ratio, C.I. confidence interval, BMI body mass index, SAPS simplified acute physiology score, SOFA Sequential Organ Failure Assessment Score, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, MELD model for end-stage liver disease, VAP ventilator-associated pneumonia, PaO2 arterial oxygen partial pressure, FiO2 inspired fraction of oxygen, CRS respiratory system compliance
  3. aPer 100 points increase of PaO2/FiO2 ratio