Skip to main content

Table 4 Multivariate logistic regression analysis, dependant variable death during ICU stay

From: Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

  Univariate logistic regression analysis Multivariate logistic regression analysis
Variable HR 95% C.I. p HR 95% C.I. p
Age 1.067 1.029–1.107 < 0.001 1.073 1.032–1.116 < 0.001
Sex (M) 1.120 0.735–1.709 0.597 –   
BMI 0.992 0.945–1.042 0.761 –   
SOFA score at ICU admission 1.215 1.095–1.349 < 0.001 1.142 1.007–1.295 0.038
SAPS II score 1.042 1.022–1.063 < 0.001 –   
Hypertension 1.906 1.182–3.073 0.008 –   
Chronic ischemic heart disease 1.053 0.556–1.992 0.875 –   
COPD (oxygen therapy/CPAP) 1.454 0.060–35.34 0.818 –   
Chronic kidney disease (CKD) 1.599 0.706–3.617 0.260 –   
CKD – dialisys 5.595 0.512–61.132 0.158 –   
Diabetes 3.583 0.793–16.195 0.097 –   
Chronic liver disease (MELD > 10) 3.583 0.793–16.195 0.097 –   
Renal replacement therapy during ICU stay 2.885 2.265–3.675 < 0.001 2.115 1.037–4.310 0.039
Early onset VAP 1.574 0.797–3.108 0.192 –   
Late-onset VAP 1.190 0.787–1.812 0.410 –   
Lowest PaO2/FiO2 within 5 daysa 0.396 0.248–0.631 < 0.001 0.383 0.239–0.613 < 0.001
CRS < 40 mL/cmH2O within 5 days 2.844 2.221–3.642 < 0.001 3.193 2.525–4.040 < 0.001
Cardiovascular complications 4.701 2.807–7.874 < 0.001 4.600 2.474–8.554 < 0.001
Neurologic complications 0.673 0.233–1.947 0.465 –   
Gastrointestinal complications 0.749 0.288–1.952 0.555 –   
Extrapulmonary infections 0.877 0.488–1.578 0.662 –   
  1. Notes: AUC of the ROC curve for the multivariate model: 0.818
  2. Abbreviations: HR hazard ratio, C.I. confidence interval, BMI body mass index, SAPS simplified acute physiology score, SOFA Sequential Organ Failure Assessment Score, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, MELD model for end-stage liver disease, VAP ventilator-associated pneumonia, PaO2 arterial oxygen partial pressure, FiO2 inspired fraction of oxygen, CRS respiratory system compliance
  3. aPer 100 points increase of PaO2/FiO2 ratio
Back to article page

Journal of Intensive Care

ISSN: 2052-0492