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Table 3 Fine and Gray’s competing-risks analysis

From: Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

  Univariate analysis Multivariate analysis
Variable SHR 95% CI p SHR 95% CI p
Age 0.968 0.959–0.978 < 0.001 0.979 0.966–0.992 0.002
Sex (M) 0.716 0.491–1.044 0.083   
BMI 0.999 0.974–1.024 0.922   
SOFA score at ICU admission 0.836 0.788–0.887 < 0.001 0.867 0.792–0.949 0.002
SAPS II score 0.973 0.959–0.987 < 0.001   
Hypertension 0.648 0.498–0.843 0.001   
Chronic ischemic heart disease 0.760 0.473–1.221 0.257   
COPD (oxygen therapy/CPAP) 0.982 0.219–4.407 0.981   
Chronic kidney disease (CKD) 0.692 0.303–1.582 0.383   
CKD –dialisys 0.532 0.061–4.640 0.568   
Diabetes 0.703 0.459–1.078 0.106   
Chronic liver disease (MELD > 10) 0.853 0.224–3.239 0.815   
Renal replacement therapy during ICU stay 0.274 0.142–0.531 < 0.001 0.381 0.220–0.660 0.001
Early onset VAP 0.844 0.600–1.188 0.331   
Late-onset VAP 0.357 0.251–0.510 < 0.001 0.283 0.197–0.407 < 0.001
Lowest PaO2/FiO2 within 5 daysa 1.729 1.312–2.280 < 0.001 1.631 1.316–2.023 < 0.001
CRS < 40 mL/cmH2O within 5 days 0.538 0.350–0.826 0.005 0.488 0.317–0.752 0.001
Cardiovascular complications 0.253 0.175–0.367 < 0.001 0.277 0.181–0.423 < 0.001
Neurologic complications 0.550 0.236–1.283 0.167 0.469 0.207–1.061 0.069
Gastrointestinal complications 0.578 0.374–0.894 0.014   
Extrapulmonary infections 0.533 0.326–0.872 0.012   
  1. Notes: Event of interest—liberation from mechanical ventilation. Competing event- death. Observation time: 28 days
  2. Abbreviations: SHR subhazard ratio, BMI body mass index, SAPS simplified acute physiology score, SOFA Sequential Organ Failure Assessment Score, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, MELD model for end-stage liver disease, PaO2 arterial oxygen partial pressure, FiO2 inspired fraction of oxygen, CRS respiratory system compliance
  3. aSHR calculated per 100 points increase of PaO2/FiO2 ratio