Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs

Table 3 Fine and Gray’s competing-risks analysis

	Univariate analysis			Multivariate analysis
Variable	SHR	95% CI	p	SHR	95% CI	p
Age	0.968	0.959–0.978	< 0.001	0.979	0.966–0.992	0.002
Sex (M)	0.716	0.491–1.044	0.083	–
BMI	0.999	0.974–1.024	0.922	–
SOFA score at ICU admission	0.836	0.788–0.887	< 0.001	0.867	0.792–0.949	0.002
SAPS II score	0.973	0.959–0.987	< 0.001	–
Hypertension	0.648	0.498–0.843	0.001	–
Chronic ischemic heart disease	0.760	0.473–1.221	0.257	–
COPD (oxygen therapy/CPAP)	0.982	0.219–4.407	0.981	–
Chronic kidney disease (CKD)	0.692	0.303–1.582	0.383	–
CKD –dialisys	0.532	0.061–4.640	0.568	–
Diabetes	0.703	0.459–1.078	0.106	–
Chronic liver disease (MELD > 10)	0.853	0.224–3.239	0.815	–
Renal replacement therapy during ICU stay	0.274	0.142–0.531	< 0.001	0.381	0.220–0.660	0.001
Early onset VAP	0.844	0.600–1.188	0.331	–
Late-onset VAP	0.357	0.251–0.510	< 0.001	0.283	0.197–0.407	< 0.001
Lowest PaO₂/FiO₂ within 5 days^a	1.729	1.312–2.280	< 0.001	1.631	1.316–2.023	< 0.001
C_RS < 40 mL/cmH₂O within 5 days	0.538	0.350–0.826	0.005	0.488	0.317–0.752	0.001
Cardiovascular complications	0.253	0.175–0.367	< 0.001	0.277	0.181–0.423	< 0.001
Neurologic complications	0.550	0.236–1.283	0.167	0.469	0.207–1.061	0.069
Gastrointestinal complications	0.578	0.374–0.894	0.014	–
Extrapulmonary infections	0.533	0.326–0.872	0.012	–

Notes: Event of interest—liberation from mechanical ventilation. Competing event- death. Observation time: 28 days
Abbreviations: SHR subhazard ratio, BMI body mass index, SAPS simplified acute physiology score, SOFA Sequential Organ Failure Assessment Score, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, MELD model for end-stage liver disease, PaO₂ arterial oxygen partial pressure, FiO₂ inspired fraction of oxygen, C_RS respiratory system compliance
^aSHR calculated per 100 points increase of PaO₂/FiO₂ ratio

ISSN: 2052-0492