From: Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis
First author | Year | Population | Region | miRNAs | Regulation mode | Specimen | DC | Internal reference types in qRT-PCR | Sample size | Diagnostic power | Ref. | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Number | Control | Number | Sen (%) | Spe (%) | AUC | ||||||||||
Wang JF | 2010 | Adults | China | miR-146a | Downregulated | Serum | 1 | mmu-miR-295 | Sepsis | 50 | SIRS | 30 | 63.3 | 100 | 0.804 | [6] |
Wang JF | 2010 | Adults | China | miR-223 | Downregulated | Serum | 1 | mmu-miR-295 | Sepsis | 50 | SIRS | 30 | 80.0 | 100 | 0.858 | [6] |
Wang H | 2012 | Adults | China | miR-15a | Downregulated | Serum | 1 | U6 | Sepsis | 166 | SIRS | 32 | 68.3 | 94.4 | 0.858 | [7] |
MA Y | 2013 | Adults | UK | miR-150 | Upregulated | Whole blood | 2 | None | Sepsis | 23 | SIRS | 22 | 72.7 | 85.7 | 0.830 | [8] |
MA Y | 2013 | Adults | UK | miR-4772-5p-iso | Downregulated | Whole blood | 2 | None | Sepsis | 23 | SIRS | 22 | 68.2 | 71.4 | 0.760 | [8] |
Wang L | 2013 | NR | China | miR-146a | Downregulated | Plasm | NR | U6 | Sepsis | 14 | SIRS | 14 | 60.0 | 87.5 | 0.813 | [9] |
Wu YH | 2013 | Children | China | miR-223 | Upregulated | Plasm | 2 | cel-miR-39 | Sepsis | 35 | SIRS | 20 | 82.9 | 85.0 | 0.919 | [14] |
Wu YH | 2014 | Children | China | miR-146a | Upregulated | Plasm | 2 | cel-miR-39 | Sepsis | 40 | SIRS | 20 | 77.5 | 77.0 | 0.815 | [15] |
Wu YH | 2014 | Children | China | miR-223 | Upregulated | Plasm | 2 | cel-miR-39 | Sepsis | 40 | SIRS | 20 | 77.5 | 55.0 | 0.678 | [15] |
Liu CL | 2015 | Children | China | miR-223 | Upregulated | Plasm | 2 | None | Sepsis | 49 | HC | 50 | 83.5 | 86.0 | 0.904 | [16] |
Yang YL | 2015 | Adults | China | miR-499 | Upregulated | Plasm | 2 | None | Sepsis | 112 | HC | 20 | 86.7 | 90.8 | 0.838 | [17] |
Han Y | 2016 | Adults | China | miR-143 | Upregulated | Serum | 1 | U6 | Sepsis | 103 | SIRS | 95 | 78.6 | 91.6 | 0.910 | [18] |
Lan C | 2016 | Adults | China | miR-155-5p | Upregulated | Serum | 3 | None | Sepsis | 105 | HC | 35 | 85.3 | 80.6 | 0.855 | [19] |
Lan C | 2016 | Adults | China | miR-133a-3p | Upregulated | Serum | 3 | None | Sepsis | 105 | HC | 35 | 97.9 | 54.8 | 0.769 | [19] |
Xu J | 2017 | Adults | China | miR-195 | Upregulated | Serum | 1 | U6 | Sepsis | 54 | SIRS | 41 | 75.6 | 70.4 | 0.776 | [20] |
Rahmel T | 2018 | Adults | German | miR-122 | Upregulated | Serum | 3 | cel-miR-54 | Sepsis | 108 | SIRS | 20 | 58.3 | 95.0 | 0.760 | [21] |
Wu XL | 2018 | Adults | China | miR-223 | Upregulated | Plasm | 1 | U6 | Sepsis | 187 | HC | 186 | 56.6 | 86.6 | 0.754 | [22] |
Abou El-Khier | 2018 | Adults | Egypt | miR-122 | Upregulated | Serum | NR | cel-miR-39 | Sepsis | 25 | LI | 25 | 100 | 100 | 1.000 | [23] |
Guo HL | 2019 | Adults | China | miR-495 | Downregulated | Serum | 2 | U6 | Sepsis | 105 | HC | 100 | 89.5 | 83.0 | 0.915 | [24] |
Karam RA | 2019 | Children | Egypt | miR-146a | Downregulated | Serum | 2 | U6 | Sepsis | 55 | HC | 60 | 86.6 | 56.6 | 0.803 | [25] |
Zhang WP | 2019 | Adults | China | miR-7110-5p | Upregulated | Plasm | 3 | miR-16 | Sepsis | 44 | HC | 21 | 84.1 | 90.5 | 0.833 | [26] |
Zhang WP | 2019 | Adults | China | miR-223-3p | Upregulated | Plasm | 3 | miR-16 | Sepsis | 44 | HC | 21 | 82.9 | 100 | 0.964 | [26] |
Lin YJ | 2019 | Adults | China | miR-210 | Upregulated | Plasm | 1 | None | Sepsis | 125 | HC | 110 | 81.0 | 80.9 | 0.852 | [27] |
Lin YJ | 2019 | Adults | China | miR-494 | Upregulated | Plasm | 1 | None | Sepsis | 125 | HC | 110 | 80.9 | 72.1 | 0.847 | [27] |
Lin YJ | 2019 | Adults | China | miR-205 | Downregulated | Plasm | 1 | None | Sepsis | 125 | HC | 110 | 78.6 | 90.5 | 0.86 | [27] |
Zhu XP | 2019 | Adults | China | miR-125b | Upregulated | Plasm | 2 | U6 | Sepsis | 120 | HC | 120 | 49.2 | 80.0 | 0.658 | [28] |
Liu GZ | 2020 | Children | China | miR-181a | Downregulated | Serum | 2 | U6 | Sepsis | 102 | LI | 50 | 83.3 | 84.0 | 0.893 | [29] |
Rabab F | 2020 | Children | Egypt | miR-101 | Upregulated | Serum | 2 | U6 | Sepsis | 50 | SIRS | 30 | 84.0 | 84.0 | 0.908 | [30] |
Rabab F | 2020 | Children | Egypt | miR-187 | Upregulated | Serum | 2 | U6 | Sepsis | 50 | SIRS | 30 | 72.0 | 76.0 | 0.789 | [30] |
Xu HM | 2020 | Adults | China | miR-19b-3p | Downregulated | Serum | 2 | U6 | Sepsis | 103 | HC | 98 | 85.4 | 85.7 | 0.921 | [31] |