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Table 1 Characteristics of the included studies and participants

From: Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis

First author

Year

Population

Region

miRNAs

Regulation mode

Specimen

DC

Internal reference types in qRT-PCR

Sample size

Diagnostic power

Ref.

Case

Number

Control

Number

Sen (%)

Spe (%)

AUC

Wang JF

2010

Adults

China

miR-146a

Downregulated

Serum

1

mmu-miR-295

Sepsis

50

SIRS

30

63.3

100

0.804

[6]

Wang JF

2010

Adults

China

miR-223

Downregulated

Serum

1

mmu-miR-295

Sepsis

50

SIRS

30

80.0

100

0.858

[6]

Wang H

2012

Adults

China

miR-15a

Downregulated

Serum

1

U6

Sepsis

166

SIRS

32

68.3

94.4

0.858

[7]

MA Y

2013

Adults

UK

miR-150

Upregulated

Whole blood

2

None

Sepsis

23

SIRS

22

72.7

85.7

0.830

[8]

MA Y

2013

Adults

UK

miR-4772-5p-iso

Downregulated

Whole blood

2

None

Sepsis

23

SIRS

22

68.2

71.4

0.760

[8]

Wang L

2013

NR

China

miR-146a

Downregulated

Plasm

NR

U6

Sepsis

14

SIRS

14

60.0

87.5

0.813

[9]

Wu YH

2013

Children

China

miR-223

Upregulated

Plasm

2

cel-miR-39

Sepsis

35

SIRS

20

82.9

85.0

0.919

[14]

Wu YH

2014

Children

China

miR-146a

Upregulated

Plasm

2

cel-miR-39

Sepsis

40

SIRS

20

77.5

77.0

0.815

[15]

Wu YH

2014

Children

China

miR-223

Upregulated

Plasm

2

cel-miR-39

Sepsis

40

SIRS

20

77.5

55.0

0.678

[15]

Liu CL

2015

Children

China

miR-223

Upregulated

Plasm

2

None

Sepsis

49

HC

50

83.5

86.0

0.904

[16]

Yang YL

2015

Adults

China

miR-499

Upregulated

Plasm

2

None

Sepsis

112

HC

20

86.7

90.8

0.838

[17]

Han Y

2016

Adults

China

miR-143

Upregulated

Serum

1

U6

Sepsis

103

SIRS

95

78.6

91.6

0.910

[18]

Lan C

2016

Adults

China

miR-155-5p

Upregulated

Serum

3

None

Sepsis

105

HC

35

85.3

80.6

0.855

[19]

Lan C

2016

Adults

China

miR-133a-3p

Upregulated

Serum

3

None

Sepsis

105

HC

35

97.9

54.8

0.769

[19]

Xu J

2017

Adults

China

miR-195

Upregulated

Serum

1

U6

Sepsis

54

SIRS

41

75.6

70.4

0.776

[20]

Rahmel T

2018

Adults

German

miR-122

Upregulated

Serum

3

cel-miR-54

Sepsis

108

SIRS

20

58.3

95.0

0.760

[21]

Wu XL

2018

Adults

China

miR-223

Upregulated

Plasm

1

U6

Sepsis

187

HC

186

56.6

86.6

0.754

[22]

Abou El-Khier

2018

Adults

Egypt

miR-122

Upregulated

Serum

NR

cel-miR-39

Sepsis

25

LI

25

100

100

1.000

[23]

Guo HL

2019

Adults

China

miR-495

Downregulated

Serum

2

U6

Sepsis

105

HC

100

89.5

83.0

0.915

[24]

Karam RA

2019

Children

Egypt

miR-146a

Downregulated

Serum

2

U6

Sepsis

55

HC

60

86.6

56.6

0.803

[25]

Zhang WP

2019

Adults

China

miR-7110-5p

Upregulated

Plasm

3

miR-16

Sepsis

44

HC

21

84.1

90.5

0.833

[26]

Zhang WP

2019

Adults

China

miR-223-3p

Upregulated

Plasm

3

miR-16

Sepsis

44

HC

21

82.9

100

0.964

[26]

Lin YJ

2019

Adults

China

miR-210

Upregulated

Plasm

1

None

Sepsis

125

HC

110

81.0

80.9

0.852

[27]

Lin YJ

2019

Adults

China

miR-494

Upregulated

Plasm

1

None

Sepsis

125

HC

110

80.9

72.1

0.847

[27]

Lin YJ

2019

Adults

China

miR-205

Downregulated

Plasm

1

None

Sepsis

125

HC

110

78.6

90.5

0.86

[27]

Zhu XP

2019

Adults

China

miR-125b

Upregulated

Plasm

2

U6

Sepsis

120

HC

120

49.2

80.0

0.658

[28]

Liu GZ

2020

Children

China

miR-181a

Downregulated

Serum

2

U6

Sepsis

102

LI

50

83.3

84.0

0.893

[29]

Rabab F

2020

Children

Egypt

miR-101

Upregulated

Serum

2

U6

Sepsis

50

SIRS

30

84.0

84.0

0.908

[30]

Rabab F

2020

Children

Egypt

miR-187

Upregulated

Serum

2

U6

Sepsis

50

SIRS

30

72.0

76.0

0.789

[30]

Xu HM

2020

Adults

China

miR-19b-3p

Downregulated

Serum

2

U6

Sepsis

103

HC

98

85.4

85.7

0.921

[31]

  1. qRT-PCR Quantitative RT-PCR, DC Diagnostic criteria, SIRS Systemic inflammatory response syndrome, HC Healthy controls, LI Local infections, Sen Sensitivity, Spe Specificity, AUC Area under the curve, Ref. References, NR No report