Skip to main content

Table 2 Fluid Balance by diuretic exposure in 48–72 h after meeting acute respiratory distress syndrome criteria

From: Fluid management in ARDS: an evaluation of current practice and the association between early diuretic use and hospital mortality

Patient characteristicsa (units) No diuretic in 48–72 h after ARDS Received diuretic in 48–72 h after ARDS P value
Pre-ARDS ICU fluid balance (total L) 0.4 [0–2.8] 0.3 [0–3.4] 0.89
0–48 h after ARDS:
 Daily fluid balance (L/24 h) 1.5 [0.4–2.7] 0.5 [−0.7–1.7] <0.0001
  Crystalloid intake (L/24 h) 1.2 [0.6–2.5] 0.6 [0.1–1.4] <0.0001
  Medication fluid intake (L/24 h) 1.1 [0.8–1.7] 1.1 [0.7–1.8] 0.92
  Nutrition intake (L/24 h) 0.5 [0.1–1.1] 0.5 [0.2–1.0] 0.86
  Free water intake (L/24 h) 0.1 [0–0.2] 0.1 [0–0.2] 0.39
  Transfusion intake (L/24 h) 0 [0–0.1] 0 [0–0.1] 0.84
  Total fluid output (L/24 h) 2.2 [1.4–3.4] 2.7 [1.9–3.4] 0.042
 Net ICU fluid balance at 48 h (total L) 4.4 [1.6–7.8] 2.5 [−1.0–6.6] 0.0047
48–72 h after ARDS:
 Daily fluid balance (L/24 h) 0.6 [−0.3–1.7] −0.9 [−2.1–0.2] <0.0001
  Crystalloid intake (L/24 h) 0.3 [0–1.0] 0 [0–0.3] 0.0007
   Less than 500 mL in 24 h 69 (59%) 84 (72%) 0.03
  Free water intake (L/24 h) 0 [0–0.1] 0 [0–0.2] 0.17
  Medication fluid intake (L/24 h) 0.9 [0.5–1.5] 1 [0.5–1.6] 0.6
  Nutrition intake (L/24 h) 0.9 [0.2–1.5] 1.1 [0.4–1.6] 0.42
  Free water intake (L/24 h) 0 [0–0.1] 0 [0–0.2] 0.17
  Transfusion intake (L/24 h) 0 [0–0] 0 [0–0] 0.05
  Total fluid output (L/24 h) 2.2 [1.6–2.9] 3.3 [2.4–4.5] <.0001
Net ICU fluid balance at 72 h (Total L) 5.3 [1.6–9.4] 1.6[−2.3–6.1] <0.0001
  1. Volume overload is defined as a net ICU fluid balance (in L) equivalent to more than 10% of admission body weight (in kg)
  2. Duration of MV refers to the duration in days of mechanical ventilation episode that includes ARDS onset
  3. Abbreviations: ARDS acute respiratory distress syndrome, ICU intensive care unit
  4. aData shown as n (%), mean (standard deviation), or median [inter-quartile range] if not normally distributed