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Table 4 Multivariable regression analyses for secondary outcomes

From: Saline versus 5% dextrose in water as a drug diluent for critically ill patients: a retrospective cohort study

Outcome Adjusted OR/β-coefficient (95% CI) p value
Hyperchloremiaa
 Diluent group (Saline) 2.09 (1.31–3.34) 0.002
 Chloride at ICU admission, mmol/L 1.15 (1.08–1.22) < 0.001
 Age, year 1.0 (0.98–1.02) 0.976
 Weight, kg 1.0 (0.99–1.02) 0.632
 APACHE III score 1.02 (1.01–1.03) < 0.001
 Time from hospitalization to ICU, days 1.0 (0.99–1.01) 0.88
 Patient category
  Planned surgical Reference  
  Unplanned surgical 2.37 (1.16–4.83) 0.018
  Medical from ward 2.23 (1.02–4.88) 0.044
  Medical from ED 1.88 (0.86–4.09) 0.112
Blood glucose SDb
 Diluent group (Saline) 0.4 (− 1.37 to 2.18) 0.655
 Blood glucose at ICU admission, mg/dL 0.03 (0–0.07) 0.089
 Age, year 0.08 (0.02–0.15) 0.01
 Weight, kg 0.07 ( 0.14 to 0.01) 0.029
 APACHE III score 0.06 (0.02–0.98) 0.006
 Time from hospitalization to ICU, days 0.02 ( 0.04 to 0.09) 0.490
 Patient category
  Planned surgical Reference  
  Unplanned surgical 0.31 ( 1.96 to 2.58) 0.788
  Medical from ward 5.72 (2.91–8.52) < 0.001
  Medical from ED 0.87 ( 1.71 to 3.44) 0.51
AKI diagnosisc   
 Diluent group (Saline) 1.11 (0.79–1.56) 0.542
 Creatinine at ICU admission, mg/dL 2.57 (1.31–5.05) 0.006
 Chloride at ICU admission, mmol/L 1.0 (0.96–1.03) 0.816
 Age, year 0.99 (0.98–1.01) 0.347
 Weight, kg 1.01 (0.99–1.02) 0.273
 APACHE III score 1.02 (1.01–1.03) < 0.001
 Time from hospitalization to ICU, days 0.99 (0.98–1.0) 0.034
 Patient category
 Planned surgical Reference  
 Unplanned surgical 0.43 (0.27–0.68) < 0.001
 Medical from ward 0.94 (0.51–1.75) 0.854
 Medical from ED 1.31 (0.72–2.38) 0.372
  1. aPatients with baseline chloride ≥ 110 mmol/L were excluded (311 patients)
  2. bPatients with blood glucose < 70 mg/dL or ≥ 180 mg/dL were excluded (200 patients)
  3. cPatients who received a diagnosis of AKI at ICU admission were excluded (205 patients)
  4. AKI acute kidney injury, APACHE III Acute Physiology and Chronic Health Evaluation III, ED emergency department, ICU intensive care unit, OR odds ratio, SD standard deviation