|
Parameters
|
Healthy
|
Sepsis
|
Septic shock
|
P
|
|---|
|
Number
|
24
|
32
|
22
|
NA
|
|
Age (years)
|
47 (44–52)
|
51 (47–58)
|
47 (42–53) b
|
0.0474
|
|
Male, n (%)
|
17 (70.8%)
|
27 (84.4%)
|
16 (72.7%) b
|
0.423
|
|
WBC (10^9/L)
|
7.58 (7.34–7.88)
|
14.22 (12.68–16.57)
|
14.30 (13.22–15.77) b
|
<0.0001
|
|
LC (10^9/L)
|
2.05 (1.90–2.15)
|
0.91 (0.77–1.09)
|
0.77 (0.68–0.92) a
|
<0.0001
|
|
SOFA score
|
NA
|
7 (5–10)
|
9 (7–11) a
|
0.047
|
|
SAPS II
|
NA
|
29 (23–34)
|
36 (26–46) a
|
0.0311
|
|
APACHE II score
|
NA
|
14 (12–17)
|
17 (15–21) a
|
0.008
|
|
CRP (mg/L)
|
1.3 (0.8–1.8)
|
126.7 (104.2–146.5)
|
131.9 (107.8–168.7) b
|
<0.0001
|
|
IgM (g/L)
|
1.78 (1.48–2.15)
|
0.84 (0.76–1.0)
|
0.83 (0.72–0.93) b
|
<0.0001
|
|
IL-6 (pg/ml)
|
10.6 (9.65–11.6)
|
80.0 (64.81–91.54)
|
88.58 (78.58–95.49) a
|
<0.0001
|
|
IL-10 (pg/ml)
|
10.09 (9.14–11.17)
|
87.6 (75.88–100.9)
|
88.43 (72.94–98.84) b
|
<0.0001
|
|
CD100+/CD4+ T cells %
|
80.9 (74.3–83.2)
|
67.0 (58.7–73.3)
|
52.8 (48.3–63.2) a
|
<0.0001
|
|
CD100+/CD8+ T cells %
|
81.2 (76.2–85.5)
|
71.5 (62.7–77.4)
|
59.8 (48.0–75.4) a
|
<0.0001
|
|
CD72+/CD19+ B cells %
|
72.8 (69.9–79.3)
|
67.9 (59.8–73.9)
|
58.5 (48.3–72.4) a
|
<0.0001
|
|
28-day mortality, n (%)
|
NA
|
7 (21.9%)
|
9 (40.9%) b
|
0.132
|
- Data are shown as median (interquartile ranges), frequencies and percentages. ANOVA and Kruskal-Wallis tests were performed for multi-group comparisons. aDenotes P < .05 and bdenotes P > .05 comparing sepsis group and septic shock group. NA Not applicable, WBC Counts of white blood cell, LC Counts of lymphocyte, SOFA Sequential organ failure assessment, SAPS II Simplified acute physiology score II, APACHE II Acute physiology and chronic health evaluation II, IgM Immunoglobulin M, CRP C-reaction protein, IL Interleukin
