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Table 5 Multivariable analysis of favourable neurological outcome in all CCPR cases and in patients divided by NLT

From: Extracorporeal cardiopulmonary resuscitation without target temperature management for out-of-hospital cardiac arrest patients prolongs the therapeutic time window: a retrospective analysis of a nationwide multicentre observational study in Japan

Variables All cases (n = 2278) P value OR (95% CI) NLT > 30 min (n = 1362) P value OR (95% CI) NLT > 45 min (n = 719) P value OR (95% CI)
Age (years) 77 (66–85) < 0.001 0.944 (0.932–0.956) 78 (68–85) 0.006 0.958 (0.929–0.988) 78 (78–85) 0.017 0.934 (0.884–0.988)
Male (%) 1457 (64%) 0.553 1.121 (0.768–1.637) 848 (62%) 0.578 0.758 (0.285–2.017) 467 (65%) 0.662 0.660 (0.103–4.245)
BCPR (%) 991 (44%) < 0.001 3.421 (2.396–4.884) 605 (44%) 0.265 1.695 (0.670–4.290) 313 (44%) 0.246 0.256 (0.025–2.564)
SR (%) 463 (20%) < 0.001 4.425 (3.037–6.447) 213 (16%) < 0.001 11.133 (4.122–30.067) 102 (14%) 0.011 9.996 (1.684–59.322)
NLT (min)a 36 (21–50) < 0.001 0.858 (0.843–0.872) 47 (38–57) 0.029 0.951 (0.910–0.995) 56 (50–63) 0.274 0.940 (0.841–1.050)
CPC 1–2 390 (17%) 20 (2%) 6 (1%)
  1. Values are median (interquartile range) or n (%) of cases
  2. CCPR conventional cardiopulmonary resuscitation, NLT no and low-flow time, OR odds ratio, CI confidence interval, BCPR bystander cardiopulmonary resuscitation, SR shockable rhythm, CPC cerebral performance category
  3. aDefined as the interval from witnessed OHCA to start of reperfusion (start of extracorporeal membrane oxygenation for ECPR or return of spontaneous circulation for CCPR)