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Table 1 Differences in clinical studies

From: Oxygen administration in patients recovering from cardiac arrest: a narrative review

  Type of study Primary outcome In-hospital mortality OR or RR for in-hospital mortality Effect of hyperoxia PaO2 ≥ (>) 300 mmHg Hyperoxia ≤ 4–24 h PaO2 value for analysis
Hyperoxia Control
Kilgannon et al. (2010) [7] Retrospective In-hospital mortality 63% 45% 1.8 (1.5–2.2) Unfavorable Yes Yes Highest
Kilgannon et al. (2011) [40] Retrospective In-hospital mortality    1.69 (1.56–2.07) Unfavorable   Yes Highest
Bellomo et al. (2011) [45] Retrospective In-hospital mortality    1.2 (1.0–1.5) Not significant Yes Yes Lowest
Jannz et al. (2012) [41] Retrospective In-hospital mortality 79% 61% 2.53 (1.07–5.96) Unfavorable No Yes Highest
Ihle et al. (2013) [46] Retrospective In-hospital mortality 47% 41% 1.20 (0.51–2.82) Not significant Yes Yes Lowest
Lee et al. (2014) [47] Retrospective In-hospital mortality    0.60 (0.23–1.62) Not significant No No  
Oh et al. (2014) [48] Retrospective In-hospital mortality 63% 52% 1.03 (0.31–3.40) Not significant Yes No Defined timepoint
Wang et al. (2014) [8] Systematic review In-hospital mortality    1.40 (1.02–1.93) Unfavorable Yes   
Vaahersalo et al. (2014) [51] Prospective CPC at 12 months    1.01 (0.998–1.01) Not significant No Yes  
Helmerhorst et al. (2015) [42] Retrospective In-hospital mortality 58% 53% 1.10 (0.95–1.27) Not significant Yes Yes Lowest
Elmer et al. (2015) [43] Retrospective In-hospital mortality    1.19 (1.02–1.39) Unfavorable Yes Yes  
Elmer et al. (2015) [43] Retrospective In-hospital mortality    0.99 (0.95–1.04) Not significant No Yes  
Johnson et al. (2017) [44] Retrospective Neurological function at discharge    5.88 (1.12–33.33) Unfavorable* Yes Yes Defined timepoint
Auenmueller et al. (2017) [49] Retrospective Survival at 5 days    0.85 (0.40–1.83) Not significant   No Defined timepoint
Christ et al. (2017) [50] Retrospective In-hospital mortality 46% 66% - Favorable   No Defined timepoint
Patel et al. (2018) [52] Systematic review In-hospital mortality    1.34 (1.08–1.67) Unfavorable Yes**   
Robert et al. (2018) [53] Prospective Neurological function at discharge 59% 52% 1.25 (1.01–1.54) Unfavorable Yes Yes Defined timepoint
  1. OR odds ratio, RR relative risk, CPC cerebral performance category
  2. *Not significant in neurological function at discharge
  3. **One of eight included studies did not use a threshold for defining hyperoxia