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Table 2 Summary of findings

From: Effects of hypertonic saline versus mannitol in patients with traumatic brain injury in prehospital, emergency department, and intensive care unit settings: a systematic review and meta-analysis

Outcomes Anticipated absolute effects* (95% CI) Relative effect (95% CI) Number of participants (studies) Certainty of the evidence (GRADE)
Risk with mannitol Risk with HS
All-cause mortality 382 per 1000 313 per 1000 (187 to 523) RR 0.82 (0.49 to 1.37) 105 (3 studies) Very low
90-days mortality 500 per 1000 270 per 1000 (115 to 635) RR 0.54 (0.23 to 1.27) 58 (2 studies) Very low
180-days mortality 356 per 1000 292 per 1000(160 to 540) RR 0.82 (0.45 to 1.52) 85 (2 studies) Very low
Good neurological outcome 709 per 1000 752 per 1000 (546 to 1000) RR 1.06 (0.77 to 1.47) 105 (3 studies) Very low
ICP - MD 1.9 lower (6.9 lower to 3.1 higher) - 58 (2 studies) Very low
Serum sodium levels - MD 2.6 higher (2.76 lower to 7.97 higher) - 105 (3 studies) Very low
  1. ICP intracranial pressure, CI confidence interval, HS hypertonic saline, MD mean deviation, RR risk ratio