Table 1 Patient characteristics and ventilator parameters on the day of admission
All patients (n = 70) | Pathogen-proven ARDS group (n = 50) | Pathogen-unproven ARDS group (n = 20) | p | |
|---|---|---|---|---|
Age, year | 66 (57–73) | 67 (59–74) | 60 (43–71) | 0.097 |
Male | 43 (61) | 32 (64) | 11 (55) | 0.589 |
SOFA score | 11 (9–13) | 11 (9–13) | 11 (10–13) | 0.700 |
APACHE II score | 29 (24–32) | 29 (24–32) | 28 (25–31) | 0.745 |
Transferred from other hospital | 26 (37) | 21 (42) | 5 (25) | 0.274 |
Prior use of antibiotics | 29 (41) | 18 (36) | 11 (55) | 0.183 |
Comorbidities | ||||
Heart failure | 1 (1) | 0 (0) | 1 (5) | 0.286 |
Stroke | 6 (9) | 5 (10) | 1 (5) | 0.666 |
COPD | 7 (10) | 4 (8) | 3 (15) | 0.399 |
Renal failure | 6 (9) | 3 (6) | 3 (15) | 0.343 |
Malignancy | 16 (23) | 13 (26) | 3 (15) | 0.529 |
Liver failure | 19 (27) | 14 (28) | 5 (25) | 1.000 |
Immunosuppression | 17 (24) | 11 (22) | 6 (30) | 0.543 |
Severity of ARDS (Berlin definition) | 0.620 | |||
Mild | 10 (14) | 6 (12) | 4 (20) | |
Moderate | 35 (47) | 27 (50) | 8 (40) | |
Severe | 27 (39) | 19 (38) | 8 (40) | |
Mechanical ventilation | ||||
PaO2/FIO2 | 127 (85–179) | 127 (82–176) | 135 (96–196) | 0.413 |
FIO2 | 0.60 (0.40–0.76) | 0.60 (0.45–0.80) | 0.53 (0.40–0.74) | 0.377 |
PEEP | 11 (8–14) | 10 (8–14) | 12 (10–14) | 0.155 |
Driving pressure | 13 (10–16) | 12 (10–14) | 14 (10–16) | 0.483 |
TV | 455 (389–529) | 460 (397–524) | 455 (364–550) | 0.716 |
TV/PBW | 8.0 (7.0–9.4) | 8.0 (7.0–10.0) | 8.0 (7.1–9.2) | 0.721 |
Septic shock | 26 (37) | 24 (48) | 2 (10) | 0.003 |