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Table 6 Cox proportional regression analysis evaluating ROX > 5.80 and ROX-HR > 6.80 for the likelihood of HFNC failure in patients initiated on HFNC for acute respiratory failure

From: Early prediction of high flow nasal cannula therapy outcomes using a modified ROX index incorporating heart rate

  

Univariate analysis

p value

Multivariate analysis

p value

ROX > 5.80

2 h

0.403 (0.213–0.763)

0.005

0.460 (0.238–0.892)

0.021

6 h

0.365 (0.187–0.714)

0.003

0.494 (0.260–1.015)

0.055

10 h

0.299 (0.142–0.626)

0.001

0.397 (0.176–0.894)

0.026

18 h

0.300 (0.119–0.756)

0.011

0.138 (0.036–0.532)

0.004

24 h

0.194 (0.067–0.563)

0.003

0.338 (0.101–1.136)

0.079

ROX-HR > 6.80

2 h

0.353 (0.178–0.702)

0.003

0.423 (0.211–0845)

0.015

6 h

0.394 (0.201–0.772)

0.007

0.408 (0.201–0.828)

0.013

10 h

0.301 (0.143–0.663)

0.002

0.369 (0.162–0.841)

0.018

18 h

0.254 (0.105–0.616)

0.002

0.252 (0.098–0.645)

0.004

24 h

0.177 (0.059–0.534)

0.002

0.234 (0.071–0.771)

0.017

  1. Variables included in the multivariate analysis: gender, acute physiologic assessment and chronic health evaluation (APACHE) II, Charlson comorbidity index and number of chest x-ray quadrants involved.