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Table 2 Lymphocyte count and outcome of the included studies

From: Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis

AuthorSmoking (%)COPD (%)Poor outcome (%)Lymphocyte count in good outcome (/μL)Lymphocyte count in poor outcome (/μL)Lymphopenia cutoffLymphopenia in good outcome (%)Lymphopenia in poor outcome (%)
Ruan et al. 2020 [7]NR2.068/150 (45%), death1420 (2140)600 (320)NRNRNR
Yang et al. 2020 [6]47.6 (CLD)20/52 (38%), death740 (840)620 (370)NRNRNR
Zhou et al. 2020 [20]5.73.154/191 (28%), death1100 (800–1500)600 (500–800)NRNRNR
Chen et al. 2020 [23]13.84.931/123 (25%), death910 (410)700 (360)NRNRNR
Huang et al. 2020 [5]7.32.413/41 (31%), ICU1000 (700–1100)400 (200–800)≤ 100015/28 (54%)11/13 (85%)
Wang et al. 2020 [24]NR2.936/138 (26%), ICU900 (600–1200)800 (500–900)NRNRNR
Cao et al. 2020 [25]5.6NR19/198 (9%), ICU1230 (860–1565)760 (530–940)≤ 10001/179 (0.6%)16/19 (84%)
Wu et al. 2020 [26]NR2.5 (CLD)84/201 (41%), ARDS1080 (720–1450)670 (490–990)NRNRNR
Liu et al. 2020 [27]NR3.753/109 (48%), ARDS1000 (800–1400)700 (400–1100)NRNRNR
Guan et al. 2020 [28]14.41.1173/1099 (15%), severe1000 (800–1400)800 (600–1000)≤ 1500584/726 (83.2%)147/153 (96.1%)
Liu et al. 2020 [29]6.410.011/78 (14%), severe1000 (680–1390)530 (300–1150)NRNRNR
Zhang et al. 2020 [10]NR2.755/221 (24%), severe900 (600–1200)700 (400–900)≤ 1100115/166 (69%)48/55 (87%)
Zhang et al. 2020 [11]6.41.458/140 (34%), severe800 (600–1200)700 (500–1000)≤ 110058/82 (70.%)46/56 (82.1%)
Wan et al. 2020 [12]6.70.7 (CLD)40/135 (29%), severe1200 (800–1600)800 (600–1000)≤ 110036/95 (38%)32/40 (80%)
Qu et al. 2020 [13]NRNR3/30 (10%), severe1010 (450)1160 (550)NRNRNR
Qin et al. 2020 [14]1.52.6286/452 (63%), severe1000 (700–1300)800 (600–1100)NRNRNR
Wang et al. 2020 [15]23.65.438/110 (34%), severe1210 (530)600 (310)NRNRNR
Feng et al. 2020 [16]4.92.815/141 (10%), severe1200 (800–1600)700 (600–1000)NRNRNR
Lei et al. 2020 [17]NRNR7/51 (13%), severe1300 (900–1700)370 (300–600)NRNRNR
Liu et al. 2020 [18]NRNR13/40 (32.5%), severe1100 (800–1400)600 (600–800)NRNRNR
Cai et al. 2020 [19]NRNR58/298 (19%), severe1300 (1000–1800)970 (650–1190)≤ 110075/240 (31.3%)39/58 (67%)
Liu et al. 2020 [21]6.68.217/61 (27%), severe1100 (900–1400)900 (700–1100)NRNRNR
Tabata et al. 2020 [22]17.36.7 (CLD)28/104 (26%), severeNRNR< 120019/76 (25%)16/28 (57.1%)
  1. Lymphocyte count presented as median (IQR) or mean (SD). Smoking includes current and/or former smoker
  2. NR not reported, CLD chronic lung disease/pulmonary disease