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Table 1 Baseline characteristics of the included studies

From: Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis

AuthorStudy designCountrySample (n)Gender (male %)Age (years)Cardiac comorbidity (%)HT (%)DM (%)
Ruan et al. 2020 [7]RetrospectiveWuhan, China150102/150 (68%)67 non-survivor and 50 survivor (median)8.734.716.7
Yang et al. 2020 [6]RetrospectiveWuhan, China5235/52 (67%)59.7 (mean)9.6NR17.3
Zhou et al. 2020 [20]RetrospectiveWuhan, China191119/191 (62%)56 (median)7.930.418.8
Chen et al. 2020 [23]RetrospectiveWuhan, China12461/124 (49%)72 non-survivor and 53 survivor (median)16.133.111.3
Huang et al. 2020 [5]RetrospectiveWuhan, China4130/41 (73%)49 (median)14.614.619.5
Wang et al. 2020 [24]RetrospectiveWuhan, China13875/138 (54%)56 (median)14.531.210.1
Cao et al. 2020 [25]RetrospectiveShanghai, China198101/198 (51%)50.1 (mean)6.121.27.6
Wu et al. 2020 [26]RetrospectiveWuhan, China20130/41 (73%)51 (median)4.019.410.9
Yanli et al. 2020 [27]RetrospectiveWuhan, China10959/109 (54%)55 (median)6.433.911.0
Guan et al. 2020 [28]RetrospectiveWuhan, China1099640/1099 (58%)47 (median)2.515.07.4
Liu et al. 2020 [29]RetrospectiveWuhan, China7839 (58%)38 (median)NR10.36.4
Zhang G et al 2020 [10]RetrospectiveWuhan, China221108/221 (48.9%)55 (median)10.024.410.0
Zhang et al. 2020 [11]RetrospectiveWuhan, China14071/140 (50.7%)57 (median)5.030.012.1
Wan et al. 2020 [12]RetrospectiveChongqing, China13572/135 (53.3%)47 (median)5.09.68.9
Qu et al. 2020 [13]RetrospectiveHuizhoi, China3016/30 (53.3%)50.5 (median)NRNRNR
Qin et al. 2020 [14]RetrospectiveWuhan, China452235/ 452 (52%)58 (median)6.029.916.6
Wang et al. 2020 [15]RetrospectiveWuhan, China11048/110 (43%)≤ 40 (53%), 41–60 (21%), > 60 (36%)6.420.913.6
Feng et al. 2020 [16]RetrospectiveWuhan, China14172/141 (51.1%)44 (median)2.714.95.7
Lei et al. 2020 [17]RetrospectiveChongqing, China5132/51 (62.7%)45 (median)NR7.87.8
Liu et al. 2020 [18]RetrospectiveWuhan, China4015/40 (37.5%)48.7 (mean)NR15.015.0
Cai et al. 2020 [19]RetrospectiveShenzhen, China298149/298 (50%)47 (median)NRNRNR
Liu et al. 2020 [21]ProspectiveBeijing, China6131/61 (50.8)40 (median)1.619.78.2
Tabata et al. 2020 [22]RetrospectiveTokyo, Japan10447/104 (45%)68 (median)NRNRNR
  1. NR not reported, DM diabetes mellitus, HT hypertension