TY - JOUR AU - Sadan, Ofer AU - Singbartl, Kai AU - Kraft, Jacqueline AU - Plancher, Joao McONeil AU - Greven, Alexander C. M. AU - Kandiah, Prem AU - Pimentel, Cederic AU - Hall, C. L. AU - Papangelou, Alexander AU - Asbury, William H. AU - Hanfelt, John J. AU - Samuels, Owen PY - 2020 DA - 2020/05/04 TI - Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage–related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial JO - Journal of Intensive Care SP - 32 VL - 8 IS - 1 AB - Recent reports have demonstrated that among patients with subarachnoid hemorrhage (SAH) treated with hypertonic NaCl, resultant hyperchloremia has been associated with the development of acute kidney injury (AKI). We report a trial comparing the effect of two hypertonic solutions with different chloride contents on the resultant serum chloride concentrations in SAH patients, with a primary outcome aimed at limiting chloride elevation. SN - 2052-0492 UR - https://doi.org/10.1186/s40560-020-00449-0 DO - 10.1186/s40560-020-00449-0 ID - Sadan2020 ER -