Variable | Pre-match | Post-match | ||||||
---|---|---|---|---|---|---|---|---|
> 1 h, n = 2114 (86.2%) | < 1 h, n = 340 (13.8%) | p value | SMD (%) | > 1 h, n = 340 (50%) | < 1 h, n = 340 (50%) | p value | SMD (%) | |
Age | 62 (48–75) | 59 (42–70) | < 0.001 | 27.4 | 60 (43–71) | 59 (42–70) | 0.757 | 1.3 |
Systolic blood pressure | 110 (90–131) | 89 (80–115) | < 0.001 | 72.5 | 95 (82–116) | 89 (80–115) | 0.037 | 9.9 |
Temperature °C | 37 (36.7–38.3) | 37.8 (37–38.7) | < 0.001 | 34.7 | 37.5 (37–38.7) | 37.8 (37–38.7) | 0.462 | 6.9 |
Heart rate | 103 (88–117) | 110 (99–123) | < 0.001 | 43.7 | 110 (96–120) | 110 (99–123) | 0.274 | 9.9 |
Respiratory rate | 19 (18–22) | 21 (18–25) | < 0.001 | 38 | 20 (18–23) | 21 (18–25) | 0.027 | 12.9 |
Lactate | 2.5 (1.5–3.5) | 2.3 (1.3–3.4) | 0.086 | 8.2 | 2.1 (1.2–3.2) | 2.3 (1.3–3.4) | 0.139 | 8.8 |
Central venous catheter | 144 (6.8%) | 37 (10.9%) | 0.008 | 9.9 | 29 (8.5%) | 37 (10.9%) | 0.300 | 4.3 |
Fluids (IVF) in the first 6 h | 1608 (76.1%) | 313 (92.1%) | < 0.001 | 40.5 | 314 (92.4%) | 313 (92.1%) | 0.886 | 0.5 |
Amount of fluids in 6 h | 955 (150–1500) | 1500 (637–2325) | < 0.001 | 63.3 | 1450 (500–2150) | 1500 (637–2325) | 0.290 | 15.5 |
Urinary output | 646 (30.6%) | 171 (50.3%) | < 0.001 | 39.9 | 159 (46.8%) | 171 (50.3%) | 0.357 | 5.8 |
Vasopressors | 299 (14.1%) | 93 (27.4%) | < 0.001 | 28.2 | 84 (24.7%) | 93 (27.4%) | 0.432 | 4.5 |
Blood cultures | 1819 (86.1%) | 321 (94.4%) | < 0.001 | 21.9 | 324 (95.3%) | 321 (94.4%) | 0.603 | 1.7 |
Blood cultures taken prior to the beginning of antibiotics | 1508 (71.3%) | 129 (37.9%) | < 0.001 | 68.5 | 138 (40.6%) | 129 (37.9%) | 0.480 | 4.4 |
Admission to ICU/SCU | 856 (40.5%) | 182 (53.5%) | < 0.001 | 26.4 | 179 (52.7%) | 182 (53.5%) | 0.818 | 1.4 |
Mechanical ventilation | 311 (14.7%) | 65 (19.1%) | 0.036 | 9.9 | 63 (18.5%) | 65 (19.1%) | 0.844 | 1 |
Confirmed diagnosis of infection | 1624 (76.8%) | 285 (83.8%) | 0.004 | 16.2 | 263 (77.4%) | 285 (83.8%) | 0.033 | 11.5 |
Inadequate antimicrobials | 610 (28.9%) | 42 (12.4%) | < 0.001 | 39.6 | 45 (13.2%) | 42 (12.4%) | 0.731 | 1.6 |
Mortality* | 240 (11.4%) | 43 (12.7%) | 0.488 | 3.1 | 40 (11.8%) | 43 (12.7%) | 0.725 | 1.6 |
Hospital stay | 10 (6–16) | 11 (6–19) | 0.002 | 21.2 | 11 (6–19) | 11 (6–19) | 0.335 | 2.3 |
SOFA score* | 4 (2–6) | 5 (3–7) | < 0.001 | 43.2 | 4 (3–7) | 5 (3–7) | 0.473 | 9.2 |
APACHE II score* | 14 (9–12) | 15 (11–19) | < 0.001 | 32.4 | 15 (9–18) | 15 (11–19) | 0.148 | 14.0 |
Charlson Index* | 1 (0–2) | 1 (0–2) | 0.010 | 18.2 | 1 (0–2) | 1 (0–2) | 0.430 | 2.2 |
h between admission and administration of antibiotics* | 6 (4–10) | 1 (1–1) | < 0.001 | - | 4 (2–8) | 1 (1–1) | < 0.001 | - |