Fig 2

MDW improves early sepsis detection when combined with each SIRS vital sign criterion. The probability of sepsis in patients presenting initially to the ED with abnormal vital signs of tachycardia (a), tachypnea (b), both tachycardia and tachypnea (c), or abnormal temperature (d) is consistently lower if the MDW is normal (solid blue line) compared to abnormal MDW (dashed red line). The probability of sepsis is also higher when a vital sign abnormality is combined with abnormal WBC (dashed purple line). When a vital sign is abnormal along with abnormal WBC, abnormal MDW indicates higher sepsis probability (dashed black line) and normal MDW indicates lower sepsis probability (dashed green line)