Baseline | |||||
Phenylephrine dose | 0 μg kg−1 min−1 | 0.5 μg kg−1 min−1 | 1 μg kg−1 min−1 | 2 μg kg−1 min−1 | 5 μg kg−1 min−1 |
MAP (mmHg) | 60 ± 3 | 64 ± 3 | 69 ± 4* | 80 ± 7‡ | 109 ± 14# |
Cerebral TOI (%) | 64.9 ± 2.6 | 64.5 ± 2.9 | 64.2 ± 4.0 | 63.4 ± 4.3 | 62.5 ± 4.3 |
T-spinal cord TOI (%) | 47.7 ± 3.7 | 47.6 ± 3.8 | 47.6 ± 3.7 | 48.4 ± 3.8 | 49.2 ± 3.7‡ |
L-spinal cord TOI (%) | 52.8 ± 2.8 | 53.3 ± 2.7 | 53.9 ± 3.3 | 54.6 ± 3.9 | 54.9 ± 4.6 |
SNP dose | 0 μg kg−1 min−1 | 0.5 μg kg−1 min−1 | 1 μg kg−1 min−1 | 2 μg kg−1 min−1 | 5 μg kg−1 min−1 |
MAP (mmHg) | 69 ± 8 | 59 ± 7* | 54 ± 6* | 49 ± 7† | 41 ± 7# |
Cerebral TOI (%) | 63.9 ± 3.4 | 63.2 ± 2.8 | 63.1 ± 2.4 | 62.4 ± 2.2 | 60.8 ± 2.6‡ |
T-spinal cord TOI (%) | 47.2 ± 3.7 | 45.7 ± 3.2 | 45.1 ± 2.9* | 43.9 ± 2.9* | 41.8 ± 3.1# |
L-spinal cord TOI (%) | 53.2 ± 4.0 | 51.8 ± 3.7 | 51.6 ± 4.3 | 50.4 ± 4.3* | 47.7 ± 4.0# |
Hypovolemia | |||||
Phenylephrine dose | 0 μg kg−1 min−1 | 0.5 μg kg−1 min−1 | 1 μg kg−1 min−1 | 2 μg kg−1 min−1 | 5 μg kg−1 min−1 |
MAP (mmHg) | 48 ± 8 | 53 ± 7 | 56 ± 6* | 60 ± 8† | 80 ± 11# |
Cerebral TOI (%) | 61.2 ± 3.1 | 61.4 ± 2.8 | 61.2 ± 2.8 | 60.3 ± 2.3 | 60.2 ± 2.3 |
T-spinal cord TOI (%) | 42.2 ± 4.7 | 43.4 ± 4.5 | 44.4 ± 3.9* | 45.1 ± 3.4* | 46.5 ± 3.6‡ |
L-spinal cord TOI (%) | 46.2 ± 3.6 | 47.6 ± 3.8 | 49.0 ± 4.3 | 49.7 ± 4.4* | 51.1 ± 4.8† |
Fluid resuscitation | |||||
Phenylephrine dose | 0 μg kg−1 min−1 | 0.5 μg kg−1 min−1 | 1 μg kg−1 min−1 | 2 μg kg−1 min−1 | 5 μg kg−1 min−1 |
MAP (mmHg) | 60 ± 7 | 61 ± 6 | 64 ± 8 | 75 ± 10‡ | 102 ± 21# |
Cerebral TOI (%) | 61.0 ± 3.5 | 60.8 ± 3.1 | 60.6 ± 2.9 | 60.3 ± 2.2 | 59.4 ± 2.0 |
T-spinal cord TOI (%) | 45.7 ± 4.2 | 45.1 ± 3.9 | 45.1 ± 3.5 | 45.9 ± 3.5 | 46.2 ± 3.8 |
L-spinal cord TOI (%) | 50.1 ± 4.3 | 49.4 ± 4.0 | 49.4 ± 3.8 | 50.3 ± 4.5 | 50.7 ± 5.1 |
SNP dose | 0 μg kg−1 min−1 | 0.5 μg kg−1 min−1 | 1 μg kg−1 min−1 | 2 μg kg−1 min−1 | 5 μg kg−1 min−1 |
MAP (mmHg) | 56 ± 7 | 48 ± 5* | 44 ± 5* | 39 ± 5‡ | 34 ± 3# |
Cerebral TOI (%) | 60.2 ± 3.0 | 59.0 ± 2.4 | 58.8 ± 3.2 | 57.5 ± 2.6* | 54.7 ± 3.0# |
T-spinal cord TOI (%) | 43.9 ± 2.9 | 41.9 ± 2.7* | 41.6 ± 2.5* | 40.4 ± 2.7† | 38.4 ± 2.6# |
L-spinal cord TOI (%) | 48.1 ± 4.0 | 46.0 ± 3.9 | 45.7 ± 4.8 | 44.2 ± 4.6* | 41.1 ± 3.2# |