Skip to main content

Table 1 Mean arterial pressure (MAP) and each tissue oxygenation index (TOI) during experiments

From: Spinal cord autoregulation using near-infrared spectroscopy under normal, hypovolemic, and post-fluid resuscitation conditions in a swine model: a comparison with cerebral autoregulation

Baseline

 Phenylephrine dose

0 μg kg−1 min−1

0.5 μg kg−1 min−1

1 μg kg−1 min−1

2 μg kg−1 min−1

5 μg kg−1 min−1

  MAP (mmHg)

60 ± 3

64 ± 3

69 ± 4*

80 ± 7‡

109 ± 14#

  Cerebral TOI (%)

64.9 ± 2.6

64.5 ± 2.9

64.2 ± 4.0

63.4 ± 4.3

62.5 ± 4.3

  T-spinal cord TOI (%)

47.7 ± 3.7

47.6 ± 3.8

47.6 ± 3.7

48.4 ± 3.8

49.2 ± 3.7‡

  L-spinal cord TOI (%)

52.8 ± 2.8

53.3 ± 2.7

53.9 ± 3.3

54.6 ± 3.9

54.9 ± 4.6

 SNP dose

0 μg kg−1 min−1

0.5 μg kg−1 min−1

1 μg kg−1 min−1

2 μg kg−1 min−1

5 μg kg−1 min−1

  MAP (mmHg)

69 ± 8

59 ± 7*

54 ± 6*

49 ± 7†

41 ± 7#

  Cerebral TOI (%)

63.9 ± 3.4

63.2 ± 2.8

63.1 ± 2.4

62.4 ± 2.2

60.8 ± 2.6‡

  T-spinal cord TOI (%)

47.2 ± 3.7

45.7 ± 3.2

45.1 ± 2.9*

43.9 ± 2.9*

41.8 ± 3.1#

  L-spinal cord TOI (%)

53.2 ± 4.0

51.8 ± 3.7

51.6 ± 4.3

50.4 ± 4.3*

47.7 ± 4.0#

Hypovolemia

 Phenylephrine dose

0 μg kg−1 min−1

0.5 μg kg−1 min−1

1 μg kg−1 min−1

2 μg kg−1 min−1

5 μg kg−1 min−1

  MAP (mmHg)

48 ± 8

53 ± 7

56 ± 6*

60 ± 8†

80 ± 11#

  Cerebral TOI (%)

61.2 ± 3.1

61.4 ± 2.8

61.2 ± 2.8

60.3 ± 2.3

60.2 ± 2.3

  T-spinal cord TOI (%)

42.2 ± 4.7

43.4 ± 4.5

44.4 ± 3.9*

45.1 ± 3.4*

46.5 ± 3.6‡

  L-spinal cord TOI (%)

46.2 ± 3.6

47.6 ± 3.8

49.0 ± 4.3

49.7 ± 4.4*

51.1 ± 4.8†

Fluid resuscitation

 Phenylephrine dose

0 μg kg−1 min−1

0.5 μg kg−1 min−1

1 μg kg−1 min−1

2 μg kg−1 min−1

5 μg kg−1 min−1

  MAP (mmHg)

60 ± 7

61 ± 6

64 ± 8

75 ± 10‡

102 ± 21#

  Cerebral TOI (%)

61.0 ± 3.5

60.8 ± 3.1

60.6 ± 2.9

60.3 ± 2.2

59.4 ± 2.0

  T-spinal cord TOI (%)

45.7 ± 4.2

45.1 ± 3.9

45.1 ± 3.5

45.9 ± 3.5

46.2 ± 3.8

  L-spinal cord TOI (%)

50.1 ± 4.3

49.4 ± 4.0

49.4 ± 3.8

50.3 ± 4.5

50.7 ± 5.1

 SNP dose

0 μg kg−1 min−1

0.5 μg kg−1 min−1

1 μg kg−1 min−1

2 μg kg−1 min−1

5 μg kg−1 min−1

  MAP (mmHg)

56 ± 7

48 ± 5*

44 ± 5*

39 ± 5‡

34 ± 3#

  Cerebral TOI (%)

60.2 ± 3.0

59.0 ± 2.4

58.8 ± 3.2

57.5 ± 2.6*

54.7 ± 3.0#

  T-spinal cord TOI (%)

43.9 ± 2.9

41.9 ± 2.7*

41.6 ± 2.5*

40.4 ± 2.7†

38.4 ± 2.6#

  L-spinal cord TOI (%)

48.1 ± 4.0

46.0 ± 3.9

45.7 ± 4.8

44.2 ± 4.6*

41.1 ± 3.2#

  1. Data are expressed as the mean ± SD. L-spinal cord TOI lumbar spinal cord TOI, SNP sodium nitroprusside, T-spinal cord TOI thoracic spinal cord TOI
  2. *P < 0.05 versus period prior to phenylephrine or SNP infusion (0 μg kg−1 min−1); †P < 0.05 versus 0 and 0.5 μg kg−1 min−1; ‡P < 0.05 versus 0, 0.5, and 1 μg kg−1 min−1; #P < 0.05 versus all other infusion doses
Back to article page

Journal of Intensive Care

ISSN: 2052-0492