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Table 1 Mean arterial pressure (MAP) and each tissue oxygenation index (TOI) during experiments

From: Spinal cord autoregulation using near-infrared spectroscopy under normal, hypovolemic, and post-fluid resuscitation conditions in a swine model: a comparison with cerebral autoregulation

Baseline
 Phenylephrine dose0 μg kg−1 min−10.5 μg kg−1 min−11 μg kg−1 min−12 μg kg−1 min−15 μg kg−1 min−1
  MAP (mmHg)60 ± 364 ± 369 ± 4*80 ± 7109 ± 14#
  Cerebral TOI (%)64.9 ± 2.664.5 ± 2.964.2 ± 4.063.4 ± 4.362.5 ± 4.3
  T-spinal cord TOI (%)47.7 ± 3.747.6 ± 3.847.6 ± 3.748.4 ± 3.849.2 ± 3.7
  L-spinal cord TOI (%)52.8 ± 2.853.3 ± 2.753.9 ± 3.354.6 ± 3.954.9 ± 4.6
 SNP dose0 μg kg−1 min−10.5 μg kg−1 min−11 μg kg−1 min−12 μg kg−1 min−15 μg kg−1 min−1
  MAP (mmHg)69 ± 859 ± 7*54 ± 6*49 ± 741 ± 7#
  Cerebral TOI (%)63.9 ± 3.463.2 ± 2.863.1 ± 2.462.4 ± 2.260.8 ± 2.6
  T-spinal cord TOI (%)47.2 ± 3.745.7 ± 3.245.1 ± 2.9*43.9 ± 2.9*41.8 ± 3.1#
  L-spinal cord TOI (%)53.2 ± 4.051.8 ± 3.751.6 ± 4.350.4 ± 4.3*47.7 ± 4.0#
Hypovolemia
 Phenylephrine dose0 μg kg−1 min−10.5 μg kg−1 min−11 μg kg−1 min−12 μg kg−1 min−15 μg kg−1 min−1
  MAP (mmHg)48 ± 853 ± 756 ± 6*60 ± 880 ± 11#
  Cerebral TOI (%)61.2 ± 3.161.4 ± 2.861.2 ± 2.860.3 ± 2.360.2 ± 2.3
  T-spinal cord TOI (%)42.2 ± 4.743.4 ± 4.544.4 ± 3.9*45.1 ± 3.4*46.5 ± 3.6
  L-spinal cord TOI (%)46.2 ± 3.647.6 ± 3.849.0 ± 4.349.7 ± 4.4*51.1 ± 4.8
Fluid resuscitation
 Phenylephrine dose0 μg kg−1 min−10.5 μg kg−1 min−11 μg kg−1 min−12 μg kg−1 min−15 μg kg−1 min−1
  MAP (mmHg)60 ± 761 ± 664 ± 875 ± 10102 ± 21#
  Cerebral TOI (%)61.0 ± 3.560.8 ± 3.160.6 ± 2.960.3 ± 2.259.4 ± 2.0
  T-spinal cord TOI (%)45.7 ± 4.245.1 ± 3.945.1 ± 3.545.9 ± 3.546.2 ± 3.8
  L-spinal cord TOI (%)50.1 ± 4.349.4 ± 4.049.4 ± 3.850.3 ± 4.550.7 ± 5.1
 SNP dose0 μg kg−1 min−10.5 μg kg−1 min−11 μg kg−1 min−12 μg kg−1 min−15 μg kg−1 min−1
  MAP (mmHg)56 ± 748 ± 5*44 ± 5*39 ± 534 ± 3#
  Cerebral TOI (%)60.2 ± 3.059.0 ± 2.458.8 ± 3.257.5 ± 2.6*54.7 ± 3.0#
  T-spinal cord TOI (%)43.9 ± 2.941.9 ± 2.7*41.6 ± 2.5*40.4 ± 2.738.4 ± 2.6#
  L-spinal cord TOI (%)48.1 ± 4.046.0 ± 3.945.7 ± 4.844.2 ± 4.6*41.1 ± 3.2#
  1. Data are expressed as the mean ± SD. L-spinal cord TOI lumbar spinal cord TOI, SNP sodium nitroprusside, T-spinal cord TOI thoracic spinal cord TOI
  2. *P < 0.05 versus period prior to phenylephrine or SNP infusion (0 μg kg−1 min−1); P < 0.05 versus 0 and 0.5 μg kg−1 min−1; P < 0.05 versus 0, 0.5, and 1 μg kg−1 min−1; #P < 0.05 versus all other infusion doses