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Table 4 Pharmacodynamic target of the time above the minimum inhibitory concentration

From: Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: a randomized controlled trial

MIC (mg/L)Standard-dose meropenem (n = 8)High-dose meropenem (n = 10)
Identified MIC, n35
• Achievement of 40%T>MIC, n (%)3 (100%)5 (100%)
• Achievement of 100%T>MIC, n (%)2 (66.7%)5 (100%)
MIC = 8, n810
• Achievement of 40%T>MIC, n (%)5 (62.5%)9 (90%)
• Achievement of 100%T>MIC, n (%)2 (25%)4 (40%)
  1. MIC minimum inhibitory concentration, %T>MIC percent of the time of antibiotic concentrations above the minimum inhibitory concentration