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Table 1 Clinical characteristics on admission to the weaning center

From: Variables predicting weaning outcome in prolonged mechanically ventilated tracheotomized patients: a retrospective study

 

All patients (n = 263)

Weaning success (n = 126)

Weaning failure (n = 137)

P valuea

Clinical characteristics

 Age (years)

70.9 (± 11.0)

71.0 (± 11.4)

70.7 (± 10.6)

0.404b

 Gender (male)

161 (61.2)

87 (69.0)

74 (54.0)

0.012c

 Body mass index (kg/m2)

26.4 (± 6.2)

25.1 (± 4.4)

27.7 (± 7.3)

< 0.001b

  Obesity (BMI ≥ 30 kg/m2)

54 (20.5)

16 (12.7)

38 (27.7)

0.003c

 Smoking history

120 (45.6)

50 (39.7)

70 (51.1)

0.063c

 APACHE-II (points)

17.7 ( 5.1)

17.6 (± 4.6)

17.9 (± 5.5)

0.350b

 Albumin (g/dL)

2.0 (± 0.5)

2.0 (± 0.5)

2.0 (± 0.5)

0.190b

 Ventilator days on admission (days)

26.7 (± 21.6)

24.2 (± 17.2)

29.0 (± 24.8)

0.034b

 Time from intubation to tracheostomy (days)

10.6 (± 6.7)

10.7 (± 6.5)

10.4 (± 6.9)

0.395b

 ECLA

11 (4.2)

8 (6.3)

3 (2.2)

0.092c

Cause of acute respiratory failure

 Pneumonia

77 (29.3)

42 (33.3)

35 (25.5)

0.166c

 Surgery

74 (28.1)

38 (30.2)

36 (26.3)

0.484c

 Sepsis (including septic shock)

29 (11.0)

14 (11.1)

15 (10.9)

0.967c

 Acute exacerbation of COPD

26 (9.9)

2 (1.6)

24 (17.5)

< 0.001c

 Cardiopulmonary resuscitation

22 (8.4)

11 (8.7)

11 (8.0)

0.837c

 Cardiac failure

8 (3.0)

4 (3.2)

4 (2.9)

0.904c

 Trauma

5 (1.9)

3 (2.4)

2 (1.7)

0.673d

 Other

22 (8.4)

12 (9.5)

10 (7.3)

0.515c

Comorbidities

 Charlson comorbidity index (points)

6.6 (± 2.4)

6.5 (± 2.4)

6.7 (± 2.5)

0.268b

 Coronary artery disease

89 (33.8)

43 (34.1)

46 (33.6)

0.925c

 COPD

65 (24.7)

15 (11.9)

50 (36.5)

< 0.001c

 Diabetes mellitus

82 (31.2)

39 (31.0)

43 (31.4)

0.939c

 Chronic heart failure

53 (20.2)

22 (17.5)

31 (22.6)

0.297c

 Renal insufficiency (GFR < 60 mL/min)

74 (28.1)

30 (23.8)

44 (32.1)

0.134c

  Hemodialysis on admission

34 (12.9)

12 (9.5)

22 (16.1)

0.115c

 Malignancy

37 (14.1)

22 (17.5)

15 (10.9)

0.129c

 Hepatopathy

13 (4.9)

8 (6.3)

5 (3.6)

0.313c

 Interstitial lung disease

12 (4.6)

7 (5.6)

5 (3.6)

0.459c

 Neuromuscular disease

12 (4.6)

7 (5.6)

5 (3.6)

0.459c

  1. Continuous variables are presented as mean values (± standard deviation); categorical variables are presented as number (%)
  2. aP value for differences between patients with weaning success and weaning failure
  3. bStudent’s t test
  4. cChi-squared test
  5. dFisher’s exact test
  6. BMI body mass index, APACHE-II Acute Physiology and Chronic Health Evaluation II score, ECLA extracorporeal lung assistance (in acute respiratory failure), COPD chronic obstructive pulmonary disease, GFR glomerular filtration rate