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Table 1 Clinical characteristics on admission to the weaning center

From: Variables predicting weaning outcome in prolonged mechanically ventilated tracheotomized patients: a retrospective study

  All patients (n = 263) Weaning success (n = 126) Weaning failure (n = 137) P valuea
Clinical characteristics
 Age (years) 70.9 (± 11.0) 71.0 (± 11.4) 70.7 (± 10.6) 0.404b
 Gender (male) 161 (61.2) 87 (69.0) 74 (54.0) 0.012c
 Body mass index (kg/m2) 26.4 (± 6.2) 25.1 (± 4.4) 27.7 (± 7.3) < 0.001b
  Obesity (BMI ≥ 30 kg/m2) 54 (20.5) 16 (12.7) 38 (27.7) 0.003c
 Smoking history 120 (45.6) 50 (39.7) 70 (51.1) 0.063c
 APACHE-II (points) 17.7 ( 5.1) 17.6 (± 4.6) 17.9 (± 5.5) 0.350b
 Albumin (g/dL) 2.0 (± 0.5) 2.0 (± 0.5) 2.0 (± 0.5) 0.190b
 Ventilator days on admission (days) 26.7 (± 21.6) 24.2 (± 17.2) 29.0 (± 24.8) 0.034b
 Time from intubation to tracheostomy (days) 10.6 (± 6.7) 10.7 (± 6.5) 10.4 (± 6.9) 0.395b
 ECLA 11 (4.2) 8 (6.3) 3 (2.2) 0.092c
Cause of acute respiratory failure
 Pneumonia 77 (29.3) 42 (33.3) 35 (25.5) 0.166c
 Surgery 74 (28.1) 38 (30.2) 36 (26.3) 0.484c
 Sepsis (including septic shock) 29 (11.0) 14 (11.1) 15 (10.9) 0.967c
 Acute exacerbation of COPD 26 (9.9) 2 (1.6) 24 (17.5) < 0.001c
 Cardiopulmonary resuscitation 22 (8.4) 11 (8.7) 11 (8.0) 0.837c
 Cardiac failure 8 (3.0) 4 (3.2) 4 (2.9) 0.904c
 Trauma 5 (1.9) 3 (2.4) 2 (1.7) 0.673d
 Other 22 (8.4) 12 (9.5) 10 (7.3) 0.515c
Comorbidities
 Charlson comorbidity index (points) 6.6 (± 2.4) 6.5 (± 2.4) 6.7 (± 2.5) 0.268b
 Coronary artery disease 89 (33.8) 43 (34.1) 46 (33.6) 0.925c
 COPD 65 (24.7) 15 (11.9) 50 (36.5) < 0.001c
 Diabetes mellitus 82 (31.2) 39 (31.0) 43 (31.4) 0.939c
 Chronic heart failure 53 (20.2) 22 (17.5) 31 (22.6) 0.297c
 Renal insufficiency (GFR < 60 mL/min) 74 (28.1) 30 (23.8) 44 (32.1) 0.134c
  Hemodialysis on admission 34 (12.9) 12 (9.5) 22 (16.1) 0.115c
 Malignancy 37 (14.1) 22 (17.5) 15 (10.9) 0.129c
 Hepatopathy 13 (4.9) 8 (6.3) 5 (3.6) 0.313c
 Interstitial lung disease 12 (4.6) 7 (5.6) 5 (3.6) 0.459c
 Neuromuscular disease 12 (4.6) 7 (5.6) 5 (3.6) 0.459c
  1. Continuous variables are presented as mean values (± standard deviation); categorical variables are presented as number (%)
  2. aP value for differences between patients with weaning success and weaning failure
  3. bStudent’s t test
  4. cChi-squared test
  5. dFisher’s exact test
  6. BMI body mass index, APACHE-II Acute Physiology and Chronic Health Evaluation II score, ECLA extracorporeal lung assistance (in acute respiratory failure), COPD chronic obstructive pulmonary disease, GFR glomerular filtration rate