Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study

Table 2 Survival analysis assessing 28-day mortality, patient characteristics, and circadian rhythm parameters of the temperature

	Univariate		Multivariate
	HR [95% CI]	p	HR [95% CI]	p
Clinical variables
Age	1.04 [1.03–1.06]	< 0.001	1.06 [1.04–1.08]	< 0.001
Sex (male)	1.73 [0.81–3.72]	0.16
Body mass index	0.91 [0.83–0.99]	0.04	0.83 (0.75–0.93)	< 0.001
Glasgow Coma Scale	0.90 [0.84–0.97]	0.005
Traumatic brain injury	2.05 [0.95–4.39]	0.07
Intracranial hypertension^a	5.70 [3.03–10.73]	< 0.001	5.60 [2.91–10.76]	< 0.001
Surgery at admission	0.74 [0.41–1.33]	0.32
ISS	1.01 [0.99–1.03]	0.26
Temperature rhythm
Period	1.00 [0.98–1.02]	0.65
Mesor	0.42 [0.27–0.66]	< 0.001	0.62 [0.37–1.03]	0.064
Amplitude	4.25 [1.58–11.41]	0.004	3.28 [1.15–9.30]	0.026

The analyses were performed using Cox regression model to estimate hazard ratios (HR) and their 95% confidence intervals (95% CIs)
^aGlasgow Coma Scale score not included in the multivariate analysis owing to collinearity with intracranial hypertension

ISSN: 2052-0492