| Unmatched group | Propensity-matched group | ||||
---|---|---|---|---|---|---|
rhTM+AT | rhTM | SMD | rhTM+AT | rhTM | SMD | |
n = 253 | n = 409 | n = 189 | n = 189 | |||
Age, mean (SD) | 71.7 (13.6) | 73.6 (13.5) | 0.134 | 71.2 (14.0) | 72.0 (14.2) | 0.057 |
Sex (male), n (%) | 86 (34.0) | 125 (30.6) | 0.073 | 59 (31.2) | 60 (31.7) | 0.011 |
Hospital type (academic), n (%) | 100 (39.5) | 89 (21.8) | 0.393 | 65 (34.4) | 62 (32.8) | 0.034 |
Hospital volume (cases/year), mean (SD) | 120.1 (46.5) | 106.4 (57.3) | 0.263 | 113.1 (42.7) | 114.9 (57.5) | 0.035 |
ICU admission, n (%) | 76 (30.0) | 114 (27.9) | 0.048 | 64 (33.9) | 58 (30.7) | 0.068 |
HCU admission, n (%) | 19 (7.5) | 24 (5.9) | 0.066 | 15 (7.9) | 15 (7.9) | < 0.001 |
Comorbidity, n (%) | ||||||
 Congestive heart failure | 26 (10.3) | 57 (13.9) | 0.112 | 21 (11.1) | 20 (10.6) | 0.017 |
 Peripheral vascular disease | 3 (1.2) | 7 (1.7) | 0.044 | 3 (1.6) | 3 (1.6) | < 0.001 |
 Cerebrovascular disease | 12 (4.7) | 20 (4.9) | 0.007 | 9 (4.8) | 7 (3.7) | 0.053 |
 Dementia | 6 (2.4) | 9 (2.2) | 0.011 | 4 (2.1) | 6 (2.1) | < 0.001 |
 Chronic pulmonary disease | 13 (5.1) | 26 (6.4) | 0.052 | 11 (5.8) | 12 (6.3) | 0.022 |
 Rheumatologic disease | 8 (3.2) | 10 (2.4) | 0.043 | 4 (2.1) | 5 (2.6) | 0.035 |
 Peptic ulcer | 6 (2.4) | 10 (2.4) | 0.005 | 6 (3.2) | 5 (2.6) | 0.031 |
 Mild liver disease | 9 (3.6) | 15 (3.7) | 0.006 | 6 (3.2) | 7 (3.7) | 0.029 |
 Diabetes without chronic complications | 27 (10.7) | 43 (10.5) | 0.005 | 21 (11.1) | 20 (10.6) | 0.017 |
 Diabetes with chronic complications | 8 (3.2) | 14 (3.4) | 0.015 | 8 (4.2) | 8 (4.2) | < 0.001 |
 Renal disease | 20 (7.9) | 28 (6.8) | 0.041 | 17 (9.0) | 15 (7.9) | 0.038 |
Consciousness level, n (%) | Â | Â | Â | Â | Â | Â |
 Alert | 80 (31.6) | 192 (46.9) | 0.318 | 73 (38.6) | 68 (36.0) | 0.055 |
 Delirium | 71 (28.1) | 83 (20.3) | 0.182 | 49 (25.9) | 53 (28.0) | 0.048 |
 Somnolence | 47 (18.6) | 47 (11.5) | 0.199 | 26 (13.8) | 24 (12.7) | 0.031 |
 Coma | 52 (20.6) | 70 (17.1) | 0.088 | 38 (20.1) | 40 (21.2) | 0.026 |
Intervention, n (%) | ||||||
 Mechanical ventilation | 203 (80.2) | 268 (65.5) | 0.336 | 144 (76.2) | 141 (74.6) | 0.037 |
 Intermittent renal replacement therapy | 62 (24.5) | 53 (13.0) | 0.299 | 37 (19.6) | 41 (21.7) | 0.052 |
 Continuous renal replacement therapy | 10 (4.0) | 11 (2.7) | 0.071 | 7 (3.7) | 6 (3.2) | 0.029 |
 Polymyxin B hemoperfusion | 43 (17.0) | 39 (9.5) | 0.221 | 24 (12.7) | 27 (14.3) | 0.046 |
 Bacterial culture collection | 244 (96.4) | 382 (93.4) | 0.139 | 180 (95.2) | 179 (94.7) | 0.024 |
 Bronchoscopy | 20 (7.9) | 16 (3.9) | 0.17 | 12 (6.3) | 12 (6.3) | < 0.001 |
Catecholamine, n (%) | ||||||
 Noradrenaline | 199 (78.7) | 232 (56.7) | 0.482 | 139 (73.5) | 138 (73.0) | 0.012 |
 Dopamine | 99 (39.1) | 213 (52.1) | 0.262 | 80 (42.3) | 84 (44.4) | 0.043 |
Platelet transfusion, n (%) | 30 (11.9) | 32 (7.8) | 0.136 | 20 (10.6) | 18 (9.5) | 0.035 |
Fresh-frozen plasma transfusion, n (%) | 28 (11.1) | 15 (3.7) | 0.286 | 10 (5.3) | 14 (7.4) | 0.087 |
Immunoglobulin, n (%) | 136 (53.8) | 125 (30.6) | 0.483 | 91 (48.1) | 85 (45.0) | 0.064 |
Heparin, n (%) | 209 (82.6) | 242 (59.2) | 0.534 | 148 (78.3) | 152 (80.4) | 0.052 |
Danaparoid, n (%) | 5 (2.0) | 8 (2.0) | 0.001 | 5 (2.6) | 4 (2.1) | 0.035 |
Sivelestat sodium, n (%) | 81 (32.0) | 101 (24.7) | 0.163 | 61 (32.3) | 62 (32.8) | 0.011 |
Low-molecular-weight heparin, n (%) | 7 (2.8) | 7 (1.7) | 0.071 | 6 (3.2) | 5 (2.6) | 0.031 |
Hydrocortisone, n (%) | 73 (28.9) | 82 (20.0) | 0.206 | 44 (23.3) | 52 (27.5) | 0.097 |
Initial antibiotic use, n (%) | ||||||
 Ampicillin | 5 (2.0) | 5 (1.2) | 0.06 | 4 (2.1) | 2 (1.1) | 0.085 |
 Ampicillin/sulbactam | 29 (11.5) | 52 (12.7) | 0.038 | 25 (13.2) | 26 (13.8) | 0.015 |
 Piperacillin/tazobactam | 48 (19.0) | 76 (18.6) | 0.01 | 37 (19.6) | 37 (19.6) | < 0.001 |
 First-generation cephalosporin | 3 (1.2) | 2 (0.5) | 0.077 | 2 (1.1) | 2 (1.1) | < 0.001 |
 Third-generation cephalosporin without effect for Pseudomonas aeruginosa | 38 (15.0) | 55 (13.4) | 0.045 | 30 (15.9) | 24 (12.7) | 0.091 |
 Fourth-generation cephalosporin | 6 (2.4) | 14 (3.4) | 0.063 | 5 (2.6) | 4 (2.1) | 0.035 |
 Carbapenem | 164 (64.8) | 262 (64.1) | 0.016 | 119 (63.0) | 116 (61.4) | 0.033 |
 Aminoglycoside | 5 (2.0) | 5 (1.2) | 0.06 | 4 (2.1) | 2 (1.1) | 0.085 |
 Fluoroquinolone | 68 (26.9) | 103 (25.2) | 0.039 | 49 (25.9) | 54 (28.6) | 0.059 |
 Macrolide | 43 (17.0) | 54 (13.2) | 0.106 | 30 (15.9) | 24 (12.7) | 0.044 |
 Tetracycline | 7 (2.8) | 30 (7.3) | 0.21 | 7 (3.7) | 5 (2.6) | 0.06 |
 Clindamycin | 12 (4.7) | 20 (4.9) | 0.007 | 8 (4.2) | 11 (5.8) | 0.073 |
 Anti-MRSA drug | 43 (17.0) | 44 (10.8) | 0.181 | 23 (12.2) | 22 (11.6) | 0.016 |
 Antifungal drug | 5 (2.0) | 5 (1.2) | 0.06 | 4 (2.1) | 4 (2.1) | < 0.001 |