Dexmedetomidine improved renal function in patients with severe sepsis: an exploratory analysis of a randomized controlled trial

Table 1 Patient characteristics

Data field	DEX group (n = 54)	non-DEX group (n = 50)	P value
Age, years, mean ± SD	70.7 ± 15.1	71.4 ± 13.2	0.80
Male subjects, n (%)	30 (56)	33 (66)	0.28
Body weight, kg, mean ± SD	53.5 ± 12.9	56.2 ± 13.8	0.30
APACHE II score, median (IQR)^a	29 (25, 31)	30 (25, 33)	0.35
SOFA score, median (IQR)^b	9 (7, 11)	11 (9, 13)	0.01
Respiratory SOFA score, median (IQR)	2 (1, 3)	2 (1, 3)	0.73
Cardiovascular SOFA score, median (IQR)	3 (2, 4)	3 (3, 4)	0.33
Neurological SOFA score, median (IQR)	1 (0, 3)	2 (0, 4)	0.47
Renal SOFA score, median (IQR)	2 (1, 2)	2 (0, 3)	0.64
Hepatic SOFA score, median (IQR)	0 (0, 1)	0 (0, 1)	0.36
Coagulation SOFA score, median (IQR)	0 (0, 2)	1 (0, 2)	0.007
Serum lactate level, mmol/L, median (IQR)^c	3.9 (2.7, 6.4)	4.5 (3.0, 8.9)	0.19
Shock, n (%)^d	33 (61)	33 (66)	0.69
Comorbidities
Immunocompromised, n (%)	10 (19)	10 (20)	1.00
Hemodialysis, n (%)	3 (6)	5 (10)	0.48
Chronic respiratory disorder, n (%)	4 (7)	4 (8)	1.00
Chronic heart failure, n (%)	2 (4)	2 (4)	1.00
Site of infection			0.76
Abdomen, n (%)	21 (39)	17 (34)
Thorax, n (%)	20 (37)	15 (30)
Urinary tract, n (%)	3 (6)	7 (14)
Skin and soft tissue, n (%)	4 (7)	4 (8)
Other, n (%)	6 (11)	7 (14)

DEX dexmedetomidine, SD standard deviation, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, IQR interquartile range
^aThe APACHE II score ranges from 0 to 71, with higher scores indicating severer disease.
^bThe SOFA score ranges from 0 to 24, with higher scores indicating more severe disease. The SOFA score consists of six organ-subscores ranges from 0 to 4.
^cSerum lactate value was measured at randomization.
^dSeptic shock was defined as a SOFA score > 2 for the cardiovascular category and a lactate level > 2 mmol/L at randomization.
We showed p<0.05 in italic font.

ISSN: 2052-0492