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Table 1 Patient characteristics

From: Dexmedetomidine improved renal function in patients with severe sepsis: an exploratory analysis of a randomized controlled trial

Data fieldDEX group
(n = 54)
non-DEX group (n = 50)P value
Age, years, mean ± SD70.7 ± 15.171.4 ± 13.20.80
Male subjects, n (%)30 (56)33 (66)0.28
Body weight, kg, mean ± SD53.5 ± 12.956.2 ± 13.80.30
APACHE II score, median (IQR)a29 (25, 31)30 (25, 33)0.35
SOFA score, median (IQR)b9 (7, 11)11 (9, 13)0.01
Respiratory SOFA score, median (IQR)2 (1, 3)2 (1, 3)0.73
Cardiovascular SOFA score, median (IQR)3 (2, 4)3 (3, 4)0.33
Neurological SOFA score, median (IQR)1 (0, 3)2 (0, 4)0.47
Renal SOFA score, median (IQR)2 (1, 2)2 (0, 3)0.64
Hepatic SOFA score, median (IQR)0 (0, 1)0 (0, 1)0.36
Coagulation SOFA score, median (IQR)0 (0, 2)1 (0, 2)0.007
Serum lactate level, mmol/L, median (IQR)c3.9 (2.7, 6.4)4.5 (3.0, 8.9)0.19
Shock, n (%)d33 (61)33 (66)0.69
Comorbidities
 Immunocompromised, n (%)10 (19)10 (20)1.00
 Hemodialysis, n (%)3 (6)5 (10)0.48
 Chronic respiratory disorder, n (%)4 (7)4 (8)1.00
 Chronic heart failure, n (%)2 (4)2 (4)1.00
Site of infection  0.76
 Abdomen, n (%)21 (39)17 (34) 
 Thorax, n (%)20 (37)15 (30) 
 Urinary tract, n (%)3 (6)7 (14) 
 Skin and soft tissue, n (%)4 (7)4 (8) 
 Other, n (%)6 (11)7 (14) 
  1. DEX dexmedetomidine, SD standard deviation, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, IQR interquartile range
  2. aThe APACHE II score ranges from 0 to 71, with higher scores indicating severer disease.
  3. bThe SOFA score ranges from 0 to 24, with higher scores indicating more severe disease. The SOFA score consists of six organ-subscores ranges from 0 to 4.
  4. cSerum lactate value was measured at randomization.
  5. dSeptic shock was defined as a SOFA score > 2 for the cardiovascular category and a lactate level > 2 mmol/L at randomization.
  6. We showed p<0.05 in italic font.