Table 3 Pharmacokinetic parameters
Variable | Predicted value (n = 17) | Calculated value (n = 17) | p value |
|---|---|---|---|
Creatinine clearance (mL/min), mean ± SD | 116.7 ± 10.3 | 161.6 ± 16.7 | 0.001 |
Elimination rate constant (h−1), mean ± SD | 0.087 ± 0.01 | 0.141 ± 0.02 | 0.004 |
Half-life (h), mean ± SD | 8.7 ± 0.6 | 6.5 ± 0.9 | 0.03 |
Volume of distribution (L), mean ± SD | 57.6 ± 2.6 | 71.8 ± 11.3 | 0.23 |