Table 1 Patient characteristics
Dexmedetomidine plus benzodiazepine, n = 141 | Benzodiazepine alone, n = 297 | p value | |
|---|---|---|---|
Female, N (%) | 23 (16.3) | 75 (25.2) | 0.04 |
Age, mean (SD) | 50.7 (11.3) | 51.6 (12.5) | 0.4 |
BMI, mean (SD) | 25.4 (5.4) | 25.9 (5.6) | 0.4 |
Pre-ICU admission seizure, N (%) | 12 (8.5) | 33 (11.1) | 0.4 |
Admission CIWA, mean (SD) | 20.4 (10.2) | 15.5 (8.7) | < 0.0001 |
Alcohol withdrawal severity, N (%) | < 0.0001 | ||
Mild (admission CIWA 1–10) | 21 (14.9) | 91 (30.6) | |
Moderate (admission CIWA 11–20) | 54 (38.3) | 128 (43.1) | |
Severe admission CIWA (> 20) | 66 (46.8) | 78 (26.3) | |
APACHE IVa. mean (SD) | 40.2 (13.0) | 39.7 (15.2) | 0.7 |
APACHE IVa within CIWA groups | |||
Mild (1–10) | 39.5 (10.4) | 38.9 (14.2) | 0.5 |
Moderate (11–20) | 38.5 (12.0) | 40.3 (16.5) | |
Severe (> 20) | 41.8 (14.6) | 39.6 (14.4) | |
Pre-ICU LOS (h), mean (SD) | 23.4 (32.4) | 9.3 (18.3) | < 0.0001 |
ICU Discharge CIWA, mean (SD) | 6.6 (4.7) | 6.4 (5.2) | 0.6 |
ICU LOS (h), mean (SD) | 88.7 (74.0) | 37.3 (36.2) | < 0.0001 |
Duration of dexmedetomidine treatment (h), mean (SD) | 60.9 (53.7) | – | |
Mild CIWA (1–10) | 47.9 (41.1) | ||
Moderate CIWA (11–20) | 80.5 (60.1) | ||
Severe CIWA (> 20) | 48.9 (46.3) | ||