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Table 1 Patients’ characteristics

From: A comprehensive protocol for ventilator weaning and extubation: a prospective observational study

  All patients PERF Non-PERF p values
(n = 248) (n = 24) (n = 224)
Age (years) 65 ± 17 64 ± 18 65 ± 17 0.8
Women, n (%) 77 (31) 7 (29) 70 (31) 1.0
APACHE II score just before extubation 13 (10–16) 12.5 (11–16) 13 (10–16) 0.8
SOFAT score just before extubation 5 (4–6) 5 (4–6.3) 5 (4–6) 0.5
RSBI (breaths/min/L) 44 ± 21 45 ± 18 44 ± 21 0.9
Duration of mechanical ventilation (days) 7 (5–11) 7.5 (5–13.3) 7 (5–11) 0.6
Reason for mechanical ventilation, n (%)     0.2
 ARDS 159 (64.1) 14 (58) 145 (65)  
 Congestive heart failure 57 (23.0) 5 (21) 52 (23)  
 Post-cardiac arrest syndrome 30 (12.1) 4 (16) 26 (12)  
 COPD exacerbation 2 (0.8) 1 (4) 1 (0.4)  
Comorbid diseases, n (%)     0.4
 COPD 17 (7) 5 (21) 12 (5)  
 Coronary artery disease 35 (14) 5 (21) 30 (13)  
 Chronic heart failure 25 (10) 4 (17) 21 (9)  
 Chronic renal failure 14 (6) 1 (4) 13 (6)  
 Diabetes mellitus 44 (18) 8 (33) 36 (16)  
 Hypertension 85 (34) 9 (38) 76 (34)  
Vital signs just before extubation
 Heart rate (beats/min) 88 ± 19 88 ± 19 88 ± 18 0.9
 MAP (mmHg) 90 ± 15 89 ± 16 90 ± 15 0.6
 RR (breaths/min) 20 ± 7 20 ± 6 20 ± 7 0.9
ABG values just before extubation
 pH 7.45 ± 0.04 7.45 ± 0.04 7.45 ± 0.04 0.5
 PaCO2 (mmHg) 38 ± 6 39 ± 5 38 ± 6 0.5
 PaO2/FiO2 301 ± 83 282 ± 88 303 ± 83 0.3
  1. Data are presented as mean ± standard deviation, median and interquartile range, or number (percentage). PERF post-extubation respiratory failure, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFAT score sequential organ failure assessment score under tracheal intubation, RSBI rapid shallow breathing index, ARDS acute respiratory distress syndrome, COPD chronic obstructive pulmonary disease, MAP mean arterial pressure, RR respiratory rate, ABG arterial blood gas, PaCO2 partial pressure of carbon dioxide, PaO2 partial pressure of arterial oxygen, FiO2 fraction of inspired oxygen