Table 4 The influence of minor variations in diagnostic criteria on the apparent incidence and related mortality of sepsis
From: Robustness of sepsis-3 criteria in critically ill patients
Core definitions and minor variations | Incidence, % (95%CI) | Agreement (%) a | p value b | Mortality, % (95%CI) | p value |
|---|---|---|---|---|---|
Infection at admission | |||||
 Sepsis-3 | |||||
▪ Core definition: SOFA increase (4-day window) | 90 (88–92) | n/a | n/a | 28 (26–31) | n/a |
▪ SOFA increase (2-day window) | 68 (66–71) | 78 | < 0.001 | 28 (25–31) | 0.50 |
▪ Absolute SOFA ≥ 2 (4-day window) | 96 (95–97) | 94 | < 0.001 | 27 (25–30) | 0.45 |
▪ Absolute SOFA ≥ 2 at onset of infection | 89 (87–91) | 88 | 0.30 | 28 (25–31) | 0.64 |
 Septic shock-3 | |||||
▪ Core definition: SOFA increase (4-day window) | 38 (35–41) | n/a | n/a | 41 (36–46) | – |
▪ SOFA increase (2-day window) | 30 (27–32) | 92 | < 0.001 | 41 (36–46) | 0.98 |
▪ Absolute SOFA ≥ 2 (4-day window) | 39 (36–42) | 99 | < 0.001 | 41 (36–45) | 0.81 |
▪ Absolute SOFA ≥ 2 at onset of infection | 37 (34–40) | 97 | 0.25 | 41 (37–46) | 0.83 |
▪ Shock-3 ignoring lactate | 42 (40–45) | 95 | < 0.001 | 41 (36–45) | 0.93 |
ICU-acquired infection | |||||
 Sepsis-3 | |||||
▪ Core definition: SOFA increase (4-day window) | 52 (48–56) | n/a | n/a | 40 (34–46) | n/a |
▪ SOFA increase (2-day window) | 22 (19–26) | 70 | < 0.001 | 42 (33–51) | 0.31 |
▪ Absolute SOFA ≥ 2 (4-day window) | 99 (97–100) | 53 | < 0.001 | 35 (31–39) | <0.01 |
▪ Absolute SOFA ≥ 2 at onset of infection | 96 (94–98) | 53 | < 0.001 | 35 (31–40) | <0.01 |
 Septic-shock-3 | |||||
▪ Core definition: SOFA increase (4-day window) | 18 (15–21) | n/a | n/a | 57 (47–67) | n/a |
▪ SOFA increase (2-day window) | 7 (5–9) | 89 | < 0.001 | 65 (48–79) | 0.05 |
▪ Absolute SOFA ≥ 2 (4-day window) | 27 (23–31) | 91 | < 0.001 | 54 (45–62) | 0.26 |
▪ Absolute SOFA ≥ 2 at onset of infection | 26 (22–30) | 90 | < 0.001 | 53 (44–61) | 0.14 |
▪ Shock-3 ignoring lactate | 28 (24–32) | 90 | < 0.001 | 50 (42–58) | 0.01 |