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Table 4 The influence of minor variations in diagnostic criteria on the apparent incidence and related mortality of sepsis

From: Robustness of sepsis-3 criteria in critically ill patients

Core definitions and minor variations Incidence, % (95%CI) Agreement (%) a p value b Mortality, % (95%CI) p value
Infection at admission
 Sepsis-3
▪ Core definition: SOFA increase (4-day window) 90 (88–92) n/a n/a 28 (26–31) n/a
▪ SOFA increase (2-day window) 68 (66–71) 78 < 0.001 28 (25–31) 0.50
▪ Absolute SOFA ≥ 2 (4-day window) 96 (95–97) 94 < 0.001 27 (25–30) 0.45
▪ Absolute SOFA ≥ 2 at onset of infection 89 (87–91) 88 0.30 28 (25–31) 0.64
 Septic shock-3
▪ Core definition: SOFA increase (4-day window) 38 (35–41) n/a n/a 41 (36–46)
▪ SOFA increase (2-day window) 30 (27–32) 92 < 0.001 41 (36–46) 0.98
▪ Absolute SOFA ≥ 2 (4-day window) 39 (36–42) 99 < 0.001 41 (36–45) 0.81
▪ Absolute SOFA ≥ 2 at onset of infection 37 (34–40) 97 0.25 41 (37–46) 0.83
▪ Shock-3 ignoring lactate 42 (40–45) 95 < 0.001 41 (36–45) 0.93
ICU-acquired infection
 Sepsis-3
▪ Core definition: SOFA increase (4-day window) 52 (48–56) n/a n/a 40 (34–46) n/a
▪ SOFA increase (2-day window) 22 (19–26) 70 < 0.001 42 (33–51) 0.31
▪ Absolute SOFA ≥ 2 (4-day window) 99 (97–100) 53 < 0.001 35 (31–39) <0.01
▪ Absolute SOFA ≥ 2 at onset of infection 96 (94–98) 53 < 0.001 35 (31–40) <0.01
 Septic-shock-3
▪ Core definition: SOFA increase (4-day window) 18 (15–21) n/a n/a 57 (47–67) n/a
▪ SOFA increase (2-day window) 7 (5–9) 89 < 0.001 65 (48–79) 0.05
▪ Absolute SOFA ≥ 2 (4-day window) 27 (23–31) 91 < 0.001 54 (45–62) 0.26
▪ Absolute SOFA ≥ 2 at onset of infection 26 (22–30) 90 < 0.001 53 (44–61) 0.14
▪ Shock-3 ignoring lactate 28 (24–32) 90 < 0.001 50 (42–58) 0.01
  1. SOFA = Sequential Organ Failure Assessment. Incidences are the apparent incidences of the various sepsis-3 variations
  2. aPercentage agreement indicates the agreement of the incidence with the incidence of the core definition (≥ 2 increase in SOFA score) of sepsis-3
  3. bMcNemar test comparing the incidence of the core definition and minor definitions