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Table 3 Incidences of sepsis and related mortality according to core definitions

From: Robustness of sepsis-3 criteria in critically ill patients

 

N

Sepsis-3 incidence,

% (95%CI)

MARS-sepsis incidence,

% (95%CI)

Agreement (%)

p value a

Sepsis-3 mortality,

% (95%CI) b

MARS-sepsis mortality,

% (95%CI) b

p value a

Complete cohort

1582

       

â–ª Infection at admission

1081

90 (88–92)

60 (57–63)

64

< 0.001

28 (26–31)

36. (33–40)

< 0.001

â–ª ICU-acquired infection

501

52 (48–56)

54 (50–58)

58

0.49

40 (34–46)

45 (39–51)

< 0.001

Probable infection cohort c

1304

       

â–ª Infection at admission c

971

90 (88–92)

61 (58–64)

65

< 0.001

29 (26–32)

37 (33–41)

< 0.001

â–ª ICU-acquired infection c

334

53 (48–59)

56 (51–62)

59

0.39

44 (37–51)

51 (42–56)

< 0.001

  

Septic shock-3 incidence,

% (95%CI) a

MARS-shock incidence,

% (95%CI) a

Agreement (%)

p value

Septic shock-3 mortality,

% (95%CI) b

MARS-shock mortality,

% (95%CI) b

 

N

       

Complete cohort

1582

       

â–ª Infection at admission

1081

38 (35–41)

27 (24–30)

80

< 0.001

41 (36–46)

50 (45–56)

< 0.001

â–ª ICU-acquired infection

501

18 (15–21)

19 (16–23)

81

0.47

57 (47–67)

69 (59–78)

< 0.001

Probable infection cohort c

1304

       

â–ª Infection at admission c

971

39(36–42)

28 (25–31)

79

< 0.001

42 (37–47)

51 (46–57)

< 0.001

â–ª ICU-acquired infection c

334

19 (15–23)

22 (18–27)

83

0.11

63 (50–74)

73 (62–82)

< 0.001

  1. ICU=intensive care unit
  2. a McNemar test comparing the incidence of sepsis-3 and MARS definitions
  3. b Mortality reflects in-hospital mortality. For all definitions, mortality of the sepsis-3 criteria was significantly lower than mortality of the MARS definitions (p < 0.001)
  4. cA subgroup of patients in whom the infection diagnosis was either possible, probable or definite based on microbiology, clinical symptoms, and radiology, as defined by post hoc assessment