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Table 3 Incidences of sepsis and related mortality according to core definitions

From: Robustness of sepsis-3 criteria in critically ill patients

  N Sepsis-3 incidence,
% (95%CI)
MARS-sepsis incidence,
% (95%CI)
Agreement (%) p value a Sepsis-3 mortality,
% (95%CI) b
MARS-sepsis mortality,
% (95%CI) b
p value a
Complete cohort 1582        
▪ Infection at admission 1081 90 (88–92) 60 (57–63) 64 < 0.001 28 (26–31) 36. (33–40) < 0.001
▪ ICU-acquired infection 501 52 (48–56) 54 (50–58) 58 0.49 40 (34–46) 45 (39–51) < 0.001
Probable infection cohort c 1304        
▪ Infection at admission c 971 90 (88–92) 61 (58–64) 65 < 0.001 29 (26–32) 37 (33–41) < 0.001
▪ ICU-acquired infection c 334 53 (48–59) 56 (51–62) 59 0.39 44 (37–51) 51 (42–56) < 0.001
   Septic shock-3 incidence,
% (95%CI) a
MARS-shock incidence,
% (95%CI) a
Agreement (%) p value Septic shock-3 mortality,
% (95%CI) b
MARS-shock mortality,
% (95%CI) b
 
N        
Complete cohort 1582        
▪ Infection at admission 1081 38 (35–41) 27 (24–30) 80 < 0.001 41 (36–46) 50 (45–56) < 0.001
▪ ICU-acquired infection 501 18 (15–21) 19 (16–23) 81 0.47 57 (47–67) 69 (59–78) < 0.001
Probable infection cohort c 1304        
▪ Infection at admission c 971 39(36–42) 28 (25–31) 79 < 0.001 42 (37–47) 51 (46–57) < 0.001
▪ ICU-acquired infection c 334 19 (15–23) 22 (18–27) 83 0.11 63 (50–74) 73 (62–82) < 0.001
  1. ICU=intensive care unit
  2. a McNemar test comparing the incidence of sepsis-3 and MARS definitions
  3. b Mortality reflects in-hospital mortality. For all definitions, mortality of the sepsis-3 criteria was significantly lower than mortality of the MARS definitions (p < 0.001)
  4. cA subgroup of patients in whom the infection diagnosis was either possible, probable or definite based on microbiology, clinical symptoms, and radiology, as defined by post hoc assessment