Table 2 Characteristics of patients with infection on admission and with ICU-acquired infection and stratified by presence of sepsis-3 criteria
From: Robustness of sepsis-3 criteria in critically ill patients
| Â | Infection at admission (N = 1081) | ICU-acquired infection (N = 501) | ||||
|---|---|---|---|---|---|---|
No sepsis-3 (N = 105) | Sepsis-3 (N = 976) | p value | No sepsis-3 (N = 241) | Sepsis-3 (N = 260) | p value | |
Age (years) | 61 (42, 69) | 64 (53, 73) | 0.005 | 62 (51, 71) | 61 (50, 71) | 0.64 |
Male | 64 (61%) | 621 (64%) | 0.59 | 175 (73%) | 177 (68%) | 0.27 |
Charlson comorbidity index | 0 (0, 2) | 1 (0, 2) | 0.002 | 0 (0, 2) | 0 (0, 2) | 0.33 |
Chronic renal insufficiencya | 9 (9%) | 114 (12%) | 0.34 | 20 (8%) | 25 (10%) | 0.6 |
APACHE IV Score | 69 (50, 89) | 83 (66, 03) | 0.001 | 76 (58, 95) | 76 (62, 99) | 0.24 |
Medical admission | 69 (66%) | 726 (74%) | 0.06 | 102 (42%) | 104 (40%) | 0.60 |
At onset of infection | ||||||
 Days from ICU admission | 0 (0, 2) | 0 (0, 0) | < 0.001 | 6 (4, 8) | 6 (4, 9) | 0.32 |
 Hospital-acquired infection | 65 (62%) | 449 (46%) | 0.002 | 100% | (100%) | – |
 Vasopressor use | 36 (35%) | 663 (68%) | < 0.001 | 98 (41%) | 141 (54%) | 0.002 |
 Mechanical ventilation | 78 (74%) | 664 (68%) | 0.19 | 189 (78%) | 240 (92%) | < 0.001 |
 Lactate measured | 37 (35%) | 676 (69%) | < 0.001 | 72 (30%) | 109 (42%) | 0.005 |
 Lactate | 1.8 (1, 4) | 3 (2, 5) | 0.002 | 2 (1, 2) | 2 (2, 4) | < 0.001 |
 ≥ 2 SIRS criteria | 88(83%) | 900 (92%) | 0.004 | 205 (85%) | 226 (87%) | 0.55 |
 SOFA score | 2 (1, 4) | 6 (4, 9) | < 0.001 | 6 (4, 8) | 8 (5, 10) | < 0.001 |
Source of infection | Â | Â | 0.08 | Â | Â | 0.39 |
 Pulmonary tract | 70 (67%) | 533 (55%) |  | 138 (57%) | 154 (59%) |  |
 Abdominal tract | 7 (7%) | 156 (16%) |  | 7 (3%) | 12 (5%) |  |
 Urinary tract | 6 (6%) | 57 (6%) |  | 1 (0%) | 1 (0%) |  |
 CRBSI | 1 (1%) | 15 (2%) |  | 36 (15%) | 25 (10%) |  |
 Other | 21 (20%) | 215 (22%) |  | 59 (24%) | 68 (26%) |  |
Infection likelihood | Â | Â | 0.02 | Â | Â | 0.13 |
â–ª None | 11 (10%) | 99 (10%) | Â | 85 (35%) | 82 (32%) | Â |
â–ª Possible | 46 (44%) | 298 (31%) | Â | 109 (45%) | 105 (40%) | Â |
â–ª Probable | 30 (29%) | 293 (30%) | Â | 31 (13%) | 43 (17%) | Â |
â–ª Definite | 18 (17%) | 286 (29%) | Â | 16 (7%) | 30 (12%) | Â |
Outcome | ||||||
 Length of ICU stay (days) | 2 (1, 6) | 4.0 (2, 10) | < .001 | 6 (3, 13) | 7 (3, 15) | 0.12 |
 Length of hospital (days) | 13 (5, 29) | 15 (7, 31) | 0.09 | 19 (9, 34) | 22 (9, 38) | 0.64 |
 ICU mortality | 8 (8%) | 197 (20%) | 0.002 | 52 (22%) | 82 (32%) | 0.01 |
 Hospital mortality | 12 (11%) | 277 (28%) | 0.001 | 72 (30%) | 103 (40%) | 0.05 |
 90-day mortality | 20 (19%) | 328 (34%) | 0.002 | 83 (35%) | 114 (44%) | 0.03 |