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Table 2 Demographics, ventilator course, and clinical course according to the two main indications of ECCO2R

From: A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO2 removal in a large metropolis area

  AE-COPD (n = 30) ARDS (n = 24)
Age (years) 66 (61–72) 66 (63–77)
Male: n (%) 12 (40%) 17 (71%)
FEV1 (L) 0.97 (0.69–1.2) NA
FEV1 (%) 35% (29.5–53) NA
PaO2/FiO2 (mmHg) NA 131 (100–190)
SAPS II: 36 (32–50) 48 (43–62)
Use of vasopressors: n (%) 10 (33%) 14 (58%)
Type of ventilatory support
 IMV: n (%) 21 (70%) 24 (100%)
 NIV: n (%) 9 (30%) NA
IMV settings before ECCO2R:
VT (ml/kg PBW) 8.0 (7.8–8.1) 5.9 (5.5–6.0)
 Applied PEEP (cmH2O) 0 (0–0) 10 (5–15.5)
 FiO2 (%) 35 (30–38) 60 (50–70)
Measured parameters under IMV before ECCO2R:
 Plateau pressure (cmH2O) NA 28 (27–29)
 Total PEEP (cmH2O) 9 (7–11) NA
 pH 7.30 (7.25–7.32) 7.24
 PaCO2 (mmHg) 67.5 (60.75–73.25) 58.0 (48.0–65.0)
ECCO2R device
 iLa Activve: n (%) 5 (17%) 6 (25%)
 Hemolung: n (%) 25 (83%) 18 (75%)
IMV settings and measured parameters at day 1 after starting ECCO2R:
VT (ml/kg PBW) 7.98 (7.70–8.10) 4.1 (3.9–4.8)*
 pH 7.39 (7.26–7.42)* 7.31 (7.24–7.36)**
 PaCO2 (mmHg) 51.0 (45.5–56.0)* 51.0 (44.5–55.7)
ECCO2R duration (days): 6.5 (3.25–8) 4 (2–6)
IMV duration (days) 10 (4.75–15.25) 8.5 (5.5–14.25)
Course of ventilator support
 IMV weaning success (IMV patients) 16 (76%) 7 (29%)
 Intubation (NIV patients) 1 (11%) NA
Mortality: n (%) 10 (31%) 17 (71%)
 Linked to ECCO2R 2 (7%) 1 (4%)
  1. Results are expressed as median (IQR) for continuous variables and count and proportion for categorical variables
  2. Abbreviations: FEV1 forced expiratory volume in 1 s, BMI body mass index, SAPS Simplified Acute Physiology Score, IMV invasive mechanical ventilation, NIV non-invasive ventilation, VT tidal volume, PBW predicted body weight, PEEP positive end-expiratory pressure
  3. *p < 0.01 as compared to values before ECCO2R
  4. **p < 0.05 as compared to values before ECCO2R