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Table 2 Demographics, ventilator course, and clinical course according to the two main indications of ECCO2R

From: A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO2 removal in a large metropolis area

 

AE-COPD (n = 30)

ARDS (n = 24)

Age (years)

66 (61–72)

66 (63–77)

Male: n (%)

12 (40%)

17 (71%)

FEV1 (L)

0.97 (0.69–1.2)

NA

FEV1 (%)

35% (29.5–53)

NA

PaO2/FiO2 (mmHg)

NA

131 (100–190)

SAPS II:

36 (32–50)

48 (43–62)

Use of vasopressors: n (%)

10 (33%)

14 (58%)

Type of ventilatory support

 IMV: n (%)

21 (70%)

24 (100%)

 NIV: n (%)

9 (30%)

NA

IMV settings before ECCO2R:

 VT (ml/kg PBW)

8.0 (7.8–8.1)

5.9 (5.5–6.0)

 Applied PEEP (cmH2O)

0 (0–0)

10 (5–15.5)

 FiO2 (%)

35 (30–38)

60 (50–70)

Measured parameters under IMV before ECCO2R:

 Plateau pressure (cmH2O)

NA

28 (27–29)

 Total PEEP (cmH2O)

9 (7–11)

NA

 pH

7.30 (7.25–7.32)

7.24

 PaCO2 (mmHg)

67.5 (60.75–73.25)

58.0 (48.0–65.0)

ECCO2R device

 iLa Activve: n (%)

5 (17%)

6 (25%)

 Hemolung: n (%)

25 (83%)

18 (75%)

IMV settings and measured parameters at day 1 after starting ECCO2R:

 VT (ml/kg PBW)

7.98 (7.70–8.10)

4.1 (3.9–4.8)*

 pH

7.39 (7.26–7.42)*

7.31 (7.24–7.36)**

 PaCO2 (mmHg)

51.0 (45.5–56.0)*

51.0 (44.5–55.7)

ECCO2R duration (days):

6.5 (3.25–8)

4 (2–6)

IMV duration (days)

10 (4.75–15.25)

8.5 (5.5–14.25)

Course of ventilator support

 IMV weaning success (IMV patients)

16 (76%)

7 (29%)

 Intubation (NIV patients)

1 (11%)

NA

Mortality: n (%)

10 (31%)

17 (71%)

 Linked to ECCO2R

2 (7%)

1 (4%)

  1. Results are expressed as median (IQR) for continuous variables and count and proportion for categorical variables
  2. Abbreviations: FEV1 forced expiratory volume in 1 s, BMI body mass index, SAPS Simplified Acute Physiology Score, IMV invasive mechanical ventilation, NIV non-invasive ventilation, VT tidal volume, PBW predicted body weight, PEEP positive end-expiratory pressure
  3. *p < 0.01 as compared to values before ECCO2R
  4. **p < 0.05 as compared to values before ECCO2R