Diagnostic accuracy and outcome measures | SIRS | SOFA | qSOFA |
---|---|---|---|
Diagnosis of sepsis | |||
Total cohort (n = 450)f | |||
Sensitivity, % (95% CI) | 85.7 (79.8–90.1) | 64.0 (56.7–70.7) | 41.5 (34.2–49.1) |
Specificity, % (95% CI) | 23.6 (18.9–29.1) | 74.0 (68.1–79.2) | 91.1 (86.8–94.0) |
Youden’s Index | 0.093 | 0.380 | 0.325 |
PPV, % (95% CI) | 42.7 (37.5–48.1) | 64.7 (57.1–71.7) | 75.6 (65.2–83.7) |
NPV, % (95% CI) | 71.3 (60.4–80.2) | 73.4 (67.2–78.8) | 70.0 (64.6–74.9) |
AUROC (95% CI) | 0.57 (0.53–0.61); p < 0.001 | 0.69 (0.64–0.73); p < 0.001 | 0.67 (0.62–0.71); p < 0.001 |
In-hospital mortality | |||
Total cohort (n = 450)f | |||
Sensitivity, % (95% CI) | 79.2 (70.6–85.9) | 76.2 (67.2–83.3) | 45.0 (35.6–54.8) |
Specificity, % (95% CI) | 19.6 (15.7–24.2) | 69.5 (64.1–74.4) | 85.5 (81.1–89.0) |
Youden’s Index | – | 0.456 | 0.304 |
AUROC (95% CI) | 0.49 (0.44–0.54); p < 0.001 | 0.74 (0.69–0.79); p < 0.001 | 0.65 (0.60–0.71); p < 0.001 |
Mortality if score ≥ 2 | 84 (23.9), n = 351 | 80 (46.2), n = 173 | 45 (50.0), n = 90 |
Mortality if score < 2 | 22 (25.3), n = 87 | 25 (10.5), n = 237 | 55 (17.2), n = 320 |
Risk ratio (95% CI) | 0.95 (0.63–1.42); p = 0.792 | 4.38 (2.93–6.57); p < 0.001 | 2.91 (2.12–3.99); p < 0.001 |
Patients with sepsis (n = 180) | |||
Mortality if score ≥ 2 | 58 (38.7), n = 150 | 63 (56.3), n = 112 | 33 (48.5), n = 68 |
Mortality if score < 2 | 10 (40.0), n = 25 | 7 (11.1), n = 63 | 32 (33.3), n = 96 |
Risk ratio (95% CI) | 0.97 (0.57–1.63); p = 0.899 | 5.06 (2.47–10.37); p < 0.001 | 1.44 (0.99–2.09); p = 0.056 |
Patients without sepsis (n = 270) | |||
Mortality if score ≥ 2 | 26 (12.9), n = 201 | 17 (27.9), n = 61 | 12 (54.5), n = 22 |
Mortality if score < 2 | 12 (19.4), n = 62 | 18 (10.3), n = 174 | 23 (10.3), n = 224 |
Risk ratio (95% CI) | 0.67 (0.36–1.24) p = 0.209 | 2.69 (1.49–4.89); p = 0.001 | 5.31 (3.08–9.15); p < 0.001 |
ICU patients with sepsis (n = 101) | |||
Mortality if score ≥ 2 | 41 (50.0), n = 82 | 48 (56.5), n = 85 | 28 (57.1), n = 49 |
Mortality if score < 2 | 10 (58.8), n = 17 | 3 (25.0), n = 12 | 23 (48.9), n = 47 |
Risk ratio (95% CI) | 0.85 (0.54–1.34); p = 0.508 | 2.26 (0.83–6.13); p = 0.041 | 1.17 (0.80–1.71); p = 0.421 |