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Table 3 Performance of SIRS, SOFA and qSOFA scores

From: Prognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study

Diagnostic accuracy and outcome measures

SIRS

SOFA

qSOFA

Diagnosis of sepsis

 Total cohort (n = 450)f

  Sensitivity, % (95% CI)

85.7 (79.8–90.1)

64.0 (56.7–70.7)

41.5 (34.2–49.1)

  Specificity, % (95% CI)

23.6 (18.9–29.1)

74.0 (68.1–79.2)

91.1 (86.8–94.0)

  Youden’s Index

0.093

0.380

0.325

  PPV, % (95% CI)

42.7 (37.5–48.1)

64.7 (57.1–71.7)

75.6 (65.2–83.7)

  NPV, % (95% CI)

71.3 (60.4–80.2)

73.4 (67.2–78.8)

70.0 (64.6–74.9)

  AUROC (95% CI)

0.57 (0.53–0.61); p < 0.001

0.69 (0.64–0.73); p < 0.001

0.67 (0.62–0.71); p < 0.001

In-hospital mortality

 Total cohort (n = 450)f

  Sensitivity, % (95% CI)

79.2 (70.6–85.9)

76.2 (67.2–83.3)

45.0 (35.6–54.8)

  Specificity, % (95% CI)

19.6 (15.7–24.2)

69.5 (64.1–74.4)

85.5 (81.1–89.0)

  Youden’s Index

0.456

0.304

  AUROC (95% CI)

0.49 (0.44–0.54); p < 0.001

0.74 (0.69–0.79); p < 0.001

0.65 (0.60–0.71); p < 0.001

  Mortality if score ≥ 2

84 (23.9), n = 351

80 (46.2), n = 173

45 (50.0), n = 90

  Mortality if score < 2

22 (25.3), n = 87

25 (10.5), n = 237

55 (17.2), n = 320

  Risk ratio (95% CI)

0.95 (0.63–1.42); p = 0.792

4.38 (2.93–6.57); p < 0.001

2.91 (2.12–3.99); p < 0.001

 Patients with sepsis (n = 180)

  Mortality if score ≥ 2

58 (38.7), n = 150

63 (56.3), n = 112

33 (48.5), n = 68

  Mortality if score < 2

10 (40.0), n = 25

7 (11.1), n = 63

32 (33.3), n = 96

  Risk ratio (95% CI)

0.97 (0.57–1.63); p = 0.899

5.06 (2.47–10.37); p < 0.001

1.44 (0.99–2.09); p = 0.056

 Patients without sepsis (n = 270)

  Mortality if score ≥ 2

26 (12.9), n = 201

17 (27.9), n = 61

12 (54.5), n = 22

  Mortality if score < 2

12 (19.4), n = 62

18 (10.3), n = 174

23 (10.3), n = 224

  Risk ratio (95% CI)

0.67 (0.36–1.24) p = 0.209

2.69 (1.49–4.89); p = 0.001

5.31 (3.08–9.15); p < 0.001

 ICU patients with sepsis (n = 101)

  Mortality if score ≥ 2

41 (50.0), n = 82

48 (56.5), n = 85

28 (57.1), n = 49

  Mortality if score < 2

10 (58.8), n = 17

3 (25.0), n = 12

23 (48.9), n = 47

  Risk ratio (95% CI)

0.85 (0.54–1.34); p = 0.508

2.26 (0.83–6.13); p = 0.041

1.17 (0.80–1.71); p = 0.421

  1. fFor SIRS 97%, for SOFA and qSOFA 91%, and for septic shock 98% of the hematological cohort contributed to the presented data
  2. AUROC area under receiver operating characteristic, CI confidence interval, ICU intensive care unit, NPV negative predictive value, PPV positive predictive value, SIRS systemic inflammatory response syndrome, SOFA sequential (sepsis-related) organ failure assessment, qSOFA quick SOFA