Table 1 Demographics and clinical characteristics of the cohort
Variable | Total cohort (n = 450) | Patients with sepsis (n = 180) | Patients without sepsis (n = 270) | p value |
|---|---|---|---|---|
Demographics | ||||
Age in years, median (IQR) | 58 (46–66) | 58 (44.5–66) | 59 (46–66) | 0.876 |
Male gender | 274 (60.9) | 106 (58.9) | 168 (62.2) | 0.478 |
Underlying malignancy | 0.177 | |||
Non-Hodgkin’s lymphoma | 113 (25.1) | 39 (21.7) | 74 (27.4) | |
Hodgkin lymphoma | 25 (5.6) | 11 (6.1) | 14 (5.2) | |
Acute myeloid leukemia | 127 (28.2) | 52 (28.9) | 75 (27.8) | |
Acute lymphocytic leukemia | 36 (8.0) | 15 (8.3) | 21 (7.8) | |
Multiple myeloma | 80 (17.8) | 30 (16.7) | 50 (18.5) | |
Chronic myeloid leukemia | 9 (2.0) | 6 (3.3) | 3 (1.1) | |
Chronic lymphocytic leukemia | 25 (5.6) | 8 (4.4) | 17 (6.3) | |
Myelodysplastic syndrome | 18 (4.0) | 10 (5.6) | 8 (3.0) | |
Other | 17 (3.8) | 9 (5.0) | 8 (3.0) | |
Disease status at admission | 0.184 | |||
Newly diagnosed | 118 (26.2) | 40 (22.2) | 78 (28.9) | |
Partial or complete remission | 202 (44.9) | 86 (47.8) | 116 (43.0) | |
Stable disease | 14 (3.1) | 5 (2.8) | 9 (3.3) | |
Progressive disease | 91 (20.2) | 34 (18.9) | 57 (21.1) | |
Unknown | 25 (5.6) | 15 (8.3) | 10 (3.7) | |
Hematopoietic stem cell transplant | 184 (40.9) | 82 (45.6) | 102 (37.8) | 0.100 |
Allogeneic | 87 (47.3) | 45 (54.9) | 42 (41.2) | |
Autologous | 94 (51.1) | 36 (43.9) | 58 (56.9) | |
Infection site (patients with sepsis) | ||||
Respiratory tract | 58 (32.2) | |||
Central line-related | 17 (9.4) | |||
Gastrointestinal tract | 16 (8.9) | |||
≥ 3 sepsis foci | 5 (2.8) | |||
Other | 18 (10.0) | |||
Unknown | 66 (36.7) | |||
Laboratory and physiological dataa, median (IQR) | ||||
White blood cell count (× 109/L) | 0.90 (0.09–6.23) | 0.60 (0.06–6.39) | 1.08 (0.14–5.8) | 0.093 |
Platelet count (× 109/L) | 31.0 (15–78) | 26.5 (13–65) | 35.0 (16–91) | 0.002 |
Creatinine (μmol/L) | 89.3 (62.8–136.1) | 103.4 (67.2–217.5) | 84.0 (61.9–116.7) | < 0.001 |
Bilirubin (μmol/L) | 13.7 (8.6–24.0) | 17.1 (8.6–46.2) | 12.0 (6.8–18.8) | < 0.001 |
MAP (mmHg) | 80 (70–90) | 73 (65–87) | 83 (74–91) | < 0.001 |
Temperature (°C) | 38.1 (37.2–38.5) | 38.2 (37.0–38.7) | 38.1 (37.6–38.4) | 0.482 |
Systolic pressure (mmHg) | 120 (100–130) | 110 (90–125) | 120 (106–132) | < 0.001 |
Heart rate (bpm) | 100 (84–116) | 108 (88–128) | 96 (84–106) | < 0.001 |
Lactate (mmol/L), ICU onlyb | 1.9 (1.16–3.1) | 2.0 (1.21–3.7) | 1.84 (1.1–2.7) | 0.226 |