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Table 1 Clinical characteristics of the population and comparison of the patients with P. aeruginosa (P. a) without mutation vs with mutation

From: Risk factors and the resistance mechanisms involved in Pseudomonas aeruginosa mutation in critically ill patients

 

Overall population

No mutation

n= 119

Mutation

n=34

p

Median

95% CI

Median

95% CI

Median

95% CI

Age (years)

64

62 - 66

65

63 - 67

61

56 - 65

0.189

SAPS II

58

55 - 63

58

56 - 63

51

41 - 67

0.356

Length of stay (days)

21

18 - 25

18

16 - 23

34

26 - 40

0.0002*

Duration of ventilation (days)

16

14 - 20.6

14.5

13 - 17

31.5

25 - 35

0.0001*

Prior hospitalization period

6

4 - 8

5

3 - 8

9

5 - 18

0.094

Colonization period

9

7 - 11

9

7 - 11

9.5

3 - 15

0.981

Infection period

10.5

7 - 13

10.5

6 - 13

10.5

2 - 15.8

0.625

Duration 1st treatment P.a 1(n: 68/30)

4

4 - 5

4.0

3 – 5.6

4.5

3 – 6

0.656

Duration 2nd treatment P.a 2(n: 41/26)

6

5 - 9

5.0

3 – 7

8.5

5.6 - 12

0.041*

Duration 3rd treatment P.a (n: 13/15)

8

2 – 10.6

6.0

1.5 – 11

9.0

2.5 - 13

0.579

Number of ATB before P. aeruginosa in ICU

2

1 - 2

2

1 - 2

2

1 - 2

0.598

Gender M/F

 

94 (79%)/25 (21%)

22 (64.7%)/12 (35.3%)

0.112

Clinical recovery no/yes

50(32.7%)/103(67.3%)

34 (28.6%) / 85 (71.4%)

16 (47.1%)/18 (52.9%)

0.061

Bacteriological recovery no/yes

121(79.1%)/32(20.9%)

89 (74.8%) / 30 (25.2%)

32 (94.1%) / 2 (5.9%)

0.016*

Death no/yes

101 (66%)/52 (34%)

79 (66.4%) / 40 (33.6%)

22 (64.7%) / 12 (35.3%)

0.840

Reason for hospitalization

 Multiple trauma

7 (4.6%)

7 (5.9%)

0 (0 %)

0.351

 Medical

75 (49%)

58 (48.7%)

17 (50 %)

 Surgical

71 (46.4%)

54 (45.4%)

17 (50%)

Sampling type

 Tracheal aspiration

 

77 (64.7%)

21 (61.8%)

0,698

 Bronchoalveolar lavage

 

18 (15.1%)

6 (17.6%)

 Blood cultures

 

17 (14.3%)

5 (14.7%)

 Intraperitoneal sample

 

3 (2.5%)

2 (5.9%)

Prior hospitalization no/yes

41 (26.8%)/112(73.2%)

33 (27.7%) / 86 (72.3%)

8 (23.5%) / 26 (76.5%)

0.826

  1. * signify that it is considered to be statistically significant with p < 0.05