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Table 1 Characteristics of patients with sepsis and major infection sites (n = 1184)

From: Variations in infection sites and mortality rates among patients in intensive care units with severe sepsis and septic shock in Japan

Characteristics All Sites
Lung Intra-abdomen Urinary tract Soft tissue Bloodstream CNS Undifferentiated
1184 367 (31.0) 311 (26.3) 218 (18.4) 129 (10.9) 67 (5.7) 23 (1.9) 69 (5.8)
Age at admission (years) 73 (64–81) 73 (65–80) 74 (66–83) 74 (63–83) 67 (58–78) 69 (57–81) 69 (63–84) 69 (58–75)
Male sex 719 (60.7) 263 (71.7) 191 (61.4) 94 (43.1) 80 (62.0) 36 (53.7) 15 (65.2) 40 (58.0)
BMI (kg/m2) 22 (19–25) 22 (19–25) 21 (19–24) 22 (19–25) 23 (21–26) 22 (19–23) 23 (21–25) 24 (20–25)
ADL (Inactive) 288 (24.3) 82 (22.3) 60 (19.4) 82 (37.6) 29 (22.7) 22 (32.8) 1 (4.3) 12 (17.9)
Charlson comorbidity index 1 (0–2) 2 (0–3) 1 (0–2) 1 (0–2) 1 (0–2) 1 (0–2) 1 (1–2) 1 (1–3)
Admission source
 ED 676 (57.2) 226 (61.6) 158 (51.1) 147 (67.4) 67 (51.9) 32 (47.8) 12 (52.2) 34 (49.3)
 Non-ED (transfer or other department) 457 (38.7) 131 (35.7) 134 (43.4) 68 (31.2) 55 (42.6) 31 (46.3) 7 (30.4) 31 (44.9)
 ICU 49 (4.1) 10 (2.7) 17 (5.5) 3 (1.4) 7 (5.4) 6 (6.0) 4 (17.4) 4 (5.8)
Septic Shock  745 (62.9) 197 (53.7) 226 (72.2) 153 (70.2) 75 (58.1) 41 (61.2) 7 (30.4) 46 (66.7)
Positive blood culture 636 (54.0) 133 (36.4) 154 (49.8) 160 (73.7) 75 (58.1) 57 (85.1) 16 (72.7) 41 (60.3)
APACHE II score 23 (17–29) 25 (18–31) 21 (16–28) 22 (17–27) 22 (15–28) 21 (17–30) 27 (20–33) 26 (18–34)
SOFA score
 All 9 (6–11) 9 (5–12) 9 (6–11) 9 (6–11) 8 (5–11) 8 (6–11) 9 (7–11) 10 (7–13)
 Respiratory 2 (1–2) 2 (2–3) 2 (1–2) 2 (1–2) 2 (1–2) 1 (0.3–2) 1 (1–2) 2 (1–2)
 Cardiovascular 3 (0–4) 2 (0–4) 3 (1–4) 3 (0–4) 3 (0–4) 2.5 (0–4) 0 (0–4) 0 (0–3)
 Hepatic 0 (0–1) 0 (0–1) 0 (0–2) 0 (0–2) 0 (0–1) 0 (0–1.8) 0 (0–1) 0 (0–2)
 Coagulation 1 (0–2) 0 (0–1) 1 (0–1) 1 (0–2) 1 (0–2) 1 (0–2) 1 (0–2) 2 (0–3)
 Renal 1 (0–3) 1 (0–3) 1 (0–3) 2 (1–3) 2 (0–3) 2 (0–3) 1 (1–2) 2 (0.3–3.8)
 Neurological 1 (0–3) 1.5 (0–3) 1 (0–2) 1 (0–3) 1 (0–2) 1 (0–2) 3 (2–3) 1 (0–3)
Broad spectrum antibiotics
 Carbapenem 627 (55.0) 159 (45.0) 182 (61.3) 127 (59.6) 79 (63.7) 30 (44.8) 10 (45.5) 40 (62.5)
 PIPC/TAZ 238 (20.9) 85 (24.1) 59 (19.9) 52 (24.4) 20 (16.1) 16 (23.9) 0 (0) 6 (9)
  1. Reported counts (proportions) of categorical and medians (interquartile range) for continuous variables. Missing data: BMI, n = 26; admission source, n = 2; APACHE II score, n = 16; SOFA score, n = 183
  2. ADL activities of daily living, APACHE acute physiology and chronic health evaluation, BMI body mass index, ED emergency department, SIRS systemic inflammatory response syndrome, SOFA sepsis-related organ failure assessment