Skip to main content

Table 1 Characteristics of the different study cohorts comprising healthy volunteers (HC), standard care patients with bacterial infections (SC), and intensive care unit (ICU) patients

From: Neutrophils are a main source of circulating suPAR predicting outcome in critical illness

  HC SC ICU ICU, sepsis ICU, no sepsis
Number of patients 27 48 87 44 43
Male/female, n 12/15 33/15 55/32 24/20 31/12
Age median (range), years 33 (22–77) 65.5 (21–90) 65 (18–97) 68 (18–97) 58 (23–92)
Days in hospital, median (range) 6.0 (2.0–25.0) 12.0 (1.0–97.0) 11.5 (1.0–97.0) 12.0 (2.0–89.0)
Days on ICU, median (range) 5.0 (1.0–79.0) 5.0 (1.0–79.0) 5.0 (1.0–37.0)
Death on ICU, n (%) 25 (28.7) 15 (34.1) 10 (23.3)
APACHE II score, median (range) 25 (4–46) 26 (12–41) 23 (4–46)
Absence of shock, n (%) 56 (64) 31 (70.5) 25 (58.1)
Leukocytes median (range), × 103/μl 5.8 (3.8–8.9) 9.3 (2.1–23) 14.1 (0.5–41.9) 15.7 (0.5–42.9) 10.6 (2.7–31.4)
WBC Neutrophils median (range), % 56.4 (37.7–68.0) 78.4 (18.0–98.0) 87.7 (16.0–97.0) 90.3 (16.0–97.0) 86.0 (57.9–94.9)
WBC Monocytes median (range), % 7.2 (3.0–12.8) 7.0 (0.1–51.0) 4.7 (0.0–18.0) 4.1 (0.0–12.2) 6.4 (0.1–18.0)
WBC Lymphocytes median (range), % 32.2 (18.2–49.0) 11.6 (1.0–39.4) 4.7 (0.0–48.0) 3.8 (0.1–48.0) 6.6 (0.0–31.2)
CRP median (range), mg/l 86.8 (0.8–341.5) 66.6 (0.5–350.0) 135.5 (2.0–350.0) 37.4 (0.5–231.0)
PCT median (range), μg/l 1.0 (0.1–100.0) 2.18 (0.1–100.0) 0.8 (0.4–68.3)
ALT median (range), U/L 21.0 (5.0–84.0) 34.5 (5.0–9079.0) 26.0 (5.0–1280) 44.0 (6.0–9079.0)
AST median (range), U/L 32.0 (15.0–168.0) 53.5 (7.0–19,969.0) 36.0 (7.0–1178) 76.0 (14.0–19,969.0)
Gamma GT median (range) U/L 49.0 (8.0–636.0) 81.0 (8.0–168.0) 67.0 (4.0–781.0) 84.0 (9.0–1923)
ALP median (range), U/L 84.0 (35.0–286.0) 106.0 (19.0–530.0) 102.0 (39.0–350.0) 115.5 (19.0–530.0)
Bilirubin (total), mg/dl 0.64 (0.15–7.91) 0.78 (0.14–27.36) 0.64 (0.14–17.0) 1.0 (0.21–27.4)
Hb median (range), mmol/l 14.4 (12.7–16.0) 12.45 (7.1–17.5) 10.2 (5.6–16.1) 9.9 (7.0–16.1) 10.6 (5.6–15.5)
Creatinine median (range), mg/dl 0.96 (0.53–5.79) 1.5 (0.24–6.0) 1.6 (0.24–6.0) 1.9 (0.4–5.88)
GFR (range), ml/min   82.4 (8.5–139.8) 45.0 (6.0–167.4) 35.2 (6.0–130.6) 52.9 (7.3–167.4)
Urea (range), mg/dl 39.0 (11.0–182.0) 64.0 (10.0–233.0) 82.0 (26.0–233.0) 60.0 (10.0–213.0)
suPAR median (range), ng/ml 2.14 (0.0–3.5) 5.9 (2.1–24.1) 9.7 (0.38–38) 10.82 (0.38–38) 8.32 (1.54–38)
uPAR positive neutrophils median (range), % of neutrophils 94.7 (43.7–99.8) 87.7 (8.83–99.6) 58.3 (3.65–99.87) 51.6 (4.62–99.85) 60.9 (10.0–99.0)
  1. Abbreviations: ALP alkaline phosphatase, ALT/AST alanine/aspartate aminotransferase, APACHE II Acute Physiology And Chronic Health Evaluation, CRP C-reactive protein, GFR glomerular filtration rate, Hb hemoglobin, HC healthy control, ICU intensive care unit, SC standard care, PCT procalcitonin, (s)UPAR (soluble) urokinase plasminogen activation receptor, WBC white blood cell count
  2. The two right columns differentiate characteristics of ICU patients with or without sepsis