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Table 3 Multivariate logistic regression of HDL-S1P, SA-S1P, S1P carrier proteins (HDL and SA), and various other inflammatory markers as predictors for sepsis severity defined as septic shock or SOFA score ≥ 8

From: Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

Variable Regression coefficient Odds ratio (95% CI) Significance (P value)
HDL-S1P, μg/L − 0.146 0.86 (0.77–0.97) < 0.05
SA-S1P, μg/L + 0.070 1.07 (0.94–1.23) ns
HDL, mg/dL − 0.320 0.73 (0.55–0.97) < 0.05
SA, g/L + 0.166 1.18 (0.85–1.64) ns
Leucocytes, ×109/L + 0.105 1.11 (0.96–1.29) ns
CRP, mg/L + 0.000 1.00 (0.98–1.02) ns
Interleukin-6, ng/L + 0.001 1.00 (1.00–1.00) ns
Procalcitonin, μg/L + 0.254 1.29 (0.87–1.91) ns
  1. S1P sphingosine 1-phosphate, HDL high-density lipoprotein, SA serum albumin, ns not significant