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Table 2 Carrier proteins and fractions of sphingosine 1-phosphate in patient groups

From: Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

Variable Control Surgical trauma Sepsis Septic shock P value*
Carrier proteins of sphingosine 1-phosphate      
 HDL, mg/dL 60.0 (53.0–64.0) 32.0 (22.0–45.2) 31.0 (18.2–40.7) 16.0 (12.0–19.0) < 0.01
 SA, g/L 41.0 (40.0–45.0) 21.0 (18.0–23.0) 21.0 (15.0–26.2) 17.0 (13.0–21.0) ns
Fractions of sphingosine 1-phosphate
 Total plasma S1P, μg/L 208.1 (186.7–216.3) 209.7 (143.3–256.6) 180.2 (123.3–253.0) 99.5 (80.2–127.2) < 0.01
 HDL-S1P, μg/L
percent of total, %
97.9 (83.5–111.6)
45.5 (44.1–47.4)
116.5 (82.3–155.4)
59.1 (49.6–64.4)
100.9 (71.2–137.7)
54.8 (48.4–64.9)
54.2 (42.8–86.7)
53.8 (44.0–62.7)
< 0.001
 SA-S1P, μg/L
percent of total, %
72.2 (61.3–75.9)
35.1 (32.4–35.6)
19.6 (7.6–31.4)
11.1 (4.5–13.6)
15.6 (8.1–33.6)
8.8 (5.2–15.7)
6.5 (3.5–13.6)
5.7 (4.6–12.1)
< 0.001
  1. HDL high-density lipoprotein, SA serum albumin, S1P sphingosine 1-phosphate, ns not significant. Data are presented as median (IQR). *P value for trend between all groups using a non-parametric ANOVA Kruskal-Wallis test