Variable | Control | Surgical trauma | Sepsis | Septic shock | P value* |
---|---|---|---|---|---|
Carrier proteins of sphingosine 1-phosphate | |||||
HDL, mg/dL | 60.0 (53.0–64.0) | 32.0 (22.0–45.2) | 31.0 (18.2–40.7) | 16.0 (12.0–19.0) | < 0.01 |
SA, g/L | 41.0 (40.0–45.0) | 21.0 (18.0–23.0) | 21.0 (15.0–26.2) | 17.0 (13.0–21.0) | ns |
Fractions of sphingosine 1-phosphate | |||||
Total plasma S1P, μg/L | 208.1 (186.7–216.3) | 209.7 (143.3–256.6) | 180.2 (123.3–253.0) | 99.5 (80.2–127.2) | < 0.01 |
HDL-S1P, μg/L percent of total, % | 97.9 (83.5–111.6) 45.5 (44.1–47.4) | 116.5 (82.3–155.4) 59.1 (49.6–64.4) | 100.9 (71.2–137.7) 54.8 (48.4–64.9) | 54.2 (42.8–86.7) 53.8 (44.0–62.7) | < 0.001 |
SA-S1P, μg/L percent of total, % | 72.2 (61.3–75.9) 35.1 (32.4–35.6) | 19.6 (7.6–31.4) 11.1 (4.5–13.6) | 15.6 (8.1–33.6) 8.8 (5.2–15.7) | 6.5 (3.5–13.6) 5.7 (4.6–12.1) | < 0.001 |