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Not an adult
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Age less than 18 years at time of ICU admission
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Active blood loss prior to transfusion
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Decrease in Hgb of 30 g/L 12 h before the index transfusion
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3 units (900 mL) of RBC 12 h before the index transfusion
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One or more transfusions 12 h after the index transfusion
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Other indicators of active blood loss
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Anemia
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Primary or secondary diagnosis of anemia
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Pregnancy
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Pregnant state during in-hospital stay
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Brain death or imminent death
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Indication of clinical brain death in ICU or death within 24 h of ICU admission
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Acute myocardial infarction (AMI)
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Primary or secondary diagnosis of AMI
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Neurocritical illness
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Critically ill patients with neurological injury or condition of the brain requiring intensive care treatment (e.g., traumatic brain injury, intracerebral, or subarachnoid hemorrhage)
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ICU admission after routine cardiac surgery
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ICU admission of post-operative cardiac patients (e.g., coronary artery bypass grafting)
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