Table 1 Exclusion criteria for study cohort
Exclusion criteria | Definition(s) |
|---|---|
Not an adult | Age less than 18 years at time of ICU admission |
Active blood loss prior to transfusion | Decrease in Hgb of 30 g/L 12 h before the index transfusion |
3 units (900 mL) of RBC 12 h before the index transfusion | |
One or more transfusions 12 h after the index transfusion | |
Other indicators of active blood loss | |
Anemia | Primary or secondary diagnosis of anemia |
Pregnancy | Pregnant state during in-hospital stay |
Brain death or imminent death | Indication of clinical brain death in ICU or death within 24 h of ICU admission |
Acute myocardial infarction (AMI) | Primary or secondary diagnosis of AMI |
Neurocritical illness | Critically ill patients with neurological injury or condition of the brain requiring intensive care treatment (e.g., traumatic brain injury, intracerebral, or subarachnoid hemorrhage) |
ICU admission after routine cardiac surgery | ICU admission of post-operative cardiac patients (e.g., coronary artery bypass grafting) |